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B2V5U0

- GSA_SULSY

UniProt

B2V5U0 - GSA_SULSY

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSSP436114:GI6I-1481-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:SYO3AOP1_1432
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001201: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000201035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_1432.

Structurei

3D structure databases

ProteinModelPortaliB2V5U0.
SMRiB2V5U0. Positions 1-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2V5U0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQKSKELF QEAQKYLVGG VNSPVRAFKA VEADPIFIKK GKGCRIWDVD
60 70 80 90 100
DNEYIDYVLS WGPLILGHAH DQVINAIKQI SNYGTSFGAP TELEVEMAKA
110 120 130 140 150
VIDAVKSVEM VRFVNSGTEA TMSAIRLARG YTKRKKIIKF DGCYHGHGDS
160 170 180 190 200
LLVSAGSGVA TLGIPGTPGI PEELASLTIV LPYNNIEAVE EAFEKYGDDI
210 220 230 240 250
ACVIIEPVAG NMGVVAPSKE YHQKLREITR KYGALLIFDE VMTGFRLSYG
260 270 280 290 300
GAQELYDIEP DLTTFGKVIG GGLPVGAYGG KGEIMEYVAP VGPVYQAGTL
310 320 330 340 350
SGNPLAMAAG LTQLQLLKQL NPYQELNEKG RFLEEGFKKI SQETGVPVVV
360 370 380 390 400
NRVGSMITVF FTDKEVVDFA TAKTSDTKKF AKFFRCMLEK GIYLPASQFE
410 420
AFFLSTAHSQ RDLEDTLNKA YECFKQLS
Length:428
Mass (Da):46,886
Last modified:July 1, 2008 - v1
Checksum:i582DC2F08585A156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD67034.1.
RefSeqiWP_012460091.1. NC_010730.1.
YP_001931588.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD67034; ACD67034; SYO3AOP1_1432.
GeneIDi6331475.
KEGGisul:SYO3AOP1_1432.
PATRICi23767733. VBISulSp94719_1491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD67034.1 .
RefSeqi WP_012460091.1. NC_010730.1.
YP_001931588.1. NC_010730.1.

3D structure databases

ProteinModelPortali B2V5U0.
SMRi B2V5U0. Positions 1-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436114.SYO3AOP1_1432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD67034 ; ACD67034 ; SYO3AOP1_1432 .
GeneIDi 6331475.
KEGGi sul:SYO3AOP1_1432.
PATRICi 23767733. VBISulSp94719_1491.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci SSP436114:GI6I-1481-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YO3AOP1.

Entry informationi

Entry nameiGSA_SULSY
AccessioniPrimary (citable) accession number: B2V5U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3