Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2V5I7 (UPPP_SULSY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SYO3AOP1_1321
OrganismSulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]
Taxonomic identifier436114 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197415

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane232 – 25221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2V5I7 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 8BDE56F55887A6D4

FASTA25228,505
        10         20         30         40         50         60 
MTTLEAVILG IVEGLTEFLP ISSTGHLILV SNLLGIQQTE QHKAFEVSIQ LGSILAVVFL 

        70         80         90        100        110        120 
YFKKFLDTNL MKRILIAFIP TGILGFVLYK IIKSLFNPYI VVFMLVFGGL LLILIELYHK 

       130        140        150        160        170        180 
NKSYDINSIY EVPYQKAFLI GVFQSLAMVP GTSRSGATIV GGLLLGLDRK TAAEFSFMLA 

       190        200        210        220        230        240 
VPTMFMATFY DVYKNRSNFN LSDWENLIVG FVVAFISALF AIKWLLKFIS NHSFIPFGIY 

       250 
RIILGILYYL WY 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YO3AOP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001080 Genomic DNA. Translation: ACD66931.1.
RefSeqYP_001931485.1. NC_010730.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436114.SYO3AOP1_1321.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD66931; ACD66931; SYO3AOP1_1321.
GeneID6332673.
KEGGsul:SYO3AOP1_1321.
PATRIC23767505. VBISulSp94719_1378.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSSP436114:GI6I-1369-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_SULSY
AccessionPrimary (citable) accession number: B2V5I7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families