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B2V5I7

- UPPP_SULSY

UniProt

B2V5I7 - UPPP_SULSY

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, SYO3AOP1_1321
Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSSP436114:GI6I-1369-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:SYO3AOP1_1321
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001201: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei74 – 9421Helical; Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Undecaprenyl-diphosphataseUniRule annotation
PRO_1000197415Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_1321.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V5I7-1 [UniParc]FASTAAdd to Basket

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MTTLEAVILG IVEGLTEFLP ISSTGHLILV SNLLGIQQTE QHKAFEVSIQ    50
LGSILAVVFL YFKKFLDTNL MKRILIAFIP TGILGFVLYK IIKSLFNPYI 100
VVFMLVFGGL LLILIELYHK NKSYDINSIY EVPYQKAFLI GVFQSLAMVP 150
GTSRSGATIV GGLLLGLDRK TAAEFSFMLA VPTMFMATFY DVYKNRSNFN 200
LSDWENLIVG FVVAFISALF AIKWLLKFIS NHSFIPFGIY RIILGILYYL 250
WY 252
Length:252
Mass (Da):28,505
Last modified:July 1, 2008 - v1
Checksum:i8BDE56F55887A6D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001080 Genomic DNA. Translation: ACD66931.1.
RefSeqiWP_012459990.1. NC_010730.1.
YP_001931485.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD66931; ACD66931; SYO3AOP1_1321.
GeneIDi6332673.
KEGGisul:SYO3AOP1_1321.
PATRICi23767505. VBISulSp94719_1378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001080 Genomic DNA. Translation: ACD66931.1 .
RefSeqi WP_012459990.1. NC_010730.1.
YP_001931485.1. NC_010730.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436114.SYO3AOP1_1321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD66931 ; ACD66931 ; SYO3AOP1_1321 .
GeneIDi 6332673.
KEGGi sul:SYO3AOP1_1321.
PATRICi 23767505. VBISulSp94719_1378.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SSP436114:GI6I-1369-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YO3AOP1.

Entry informationi

Entry nameiUPPP_SULSY
AccessioniPrimary (citable) accession number: B2V5I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi