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B2V3C3

- PUR9_CLOBA

UniProt

B2V3C3 - PUR9_CLOBA

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, CLH_1043
Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCBOT508767:GHKO-1039-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:CLH_1043
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001738: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000096053Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi508767.CLH_1043.

Structurei

3D structure databases

ProteinModelPortaliB2V3C3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V3C3-1 [UniParc]FASTAAdd to Basket

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MKKRALISVF NKDGVLDFAE FLVSKDIEIV STGGTYKYLK ENGIDVIEIN    50
EVTNFPEMLD GRVKTLHPLV HAGILAIRDN KEHMKVLEER EIHTIDYVVV 100
NLYPFFEKVK EDLTFEEKVE FIDIGGPTML RAAAKNFQDV TVISNINDYE 150
VVKNEIENAG QVSLKTKKKL AGKVFNLMSA YDGAIANFML ADEEEYPEYL 200
SVSYKKMQNL RYGENSHQSA AVYSSTMVDG AMNTFETLNG KELSYNNFKD 250
VDIAWKCANE FDEPACCALK HNTPCGVATG ENSYEAYMKA YEVDPTSIFG 300
GIIGFNRKVD KKTAQEMVKI FLEVIAAPDY DEDALEVLKT KKNLRVLKFH 350
NTPKAEKCMV TVDGAILVQD EDNKLIDEIK VVTEKKPSDE EMEDLLFGMK 400
VVKYVKSNAI VVAHNGIALG IGGGQVNRIW PTEDALRRGK GATILASDAF 450
FPFRDVVDKA AEGGIKAIIQ PGGSMRDQES IDACNEHGIA MVFTGFRHFK 500
H 501
Length:501
Mass (Da):56,017
Last modified:July 1, 2008 - v1
Checksum:iBF99BF15EFC83884
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001078 Genomic DNA. Translation: ACD52681.1.
RefSeqiWP_012450774.1. NC_010723.1.
YP_001920437.1. NC_010723.1.

Genome annotation databases

EnsemblBacteriaiACD52681; ACD52681; CLH_1043.
GeneIDi6317830.
KEGGicbt:CLH_1043.
PATRICi19418348. VBICloBot115804_0971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001078 Genomic DNA. Translation: ACD52681.1 .
RefSeqi WP_012450774.1. NC_010723.1.
YP_001920437.1. NC_010723.1.

3D structure databases

ProteinModelPortali B2V3C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 508767.CLH_1043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD52681 ; ACD52681 ; CLH_1043 .
GeneIDi 6317830.
KEGGi cbt:CLH_1043.
PATRICi 19418348. VBICloBot115804_0971.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CBOT508767:GHKO-1039-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Alaska E43 / Type E3.

Entry informationi

Entry nameiPUR9_CLOBA
AccessioniPrimary (citable) accession number: B2V3C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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