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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. no protein annotated in this organism
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:CLH_1039
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000959731 – 235Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST235

Structurei

3D structure databases

ProteinModelPortaliB2V3B9.
SMRiB2V3B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiPOG091H02H7.

Family and domain databases

CDDicd01415. SAICAR_synt_PurC. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiView protein in InterPro
IPR028923. SAICAR_synt/ADE2_N.
IPR033934. SAICAR_synt_PurC.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
PANTHERiPTHR43599:SF3. PTHR43599:SF3. 1 hit.
PfamiView protein in Pfam
PF01259. SAICAR_synt. 1 hit.
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiView protein in PROSITE
PS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V3B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLEMLYEG KAKQIYATDK ADEVVIYYKD DATAFNGEKK GQITDKGVMN
60 70 80 90 100
NKITSILFEQ LEKQGIKTHF IKKLNDREQL CKKVEIVPLE VIVRNVAAGS
110 120 130 140 150
MAKRLGLEEG TKLKTTVFEF SYKDDELGDP LINSYHAVAI GAATFEEIDT
160 170 180 190 200
ILEMTAKINN ILKEAFAKEN INLIDFKIEF GKCADGTIVL ADEISPDTCR
210 220 230
FWDATTGEKL DKDRFRRDLG NVEDAYIEIL KRISK
Length:235
Mass (Da):26,647
Last modified:July 1, 2008 - v1
Checksum:i4EDE409125D77A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA. Translation: ACD53164.1.
RefSeqiWP_003369697.1. NC_010723.1.

Genome annotation databases

EnsemblBacteriaiACD53164; ACD53164; CLH_1039.
KEGGicbt:CLH_1039.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPUR7_CLOBA
AccessioniPrimary (citable) accession number: B2V3B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: June 7, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families