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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processSporulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:CLH_0842
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001308081 – 143Anti-sigma F factorAdd BLAST143

Structurei

3D structure databases

ProteinModelPortaliB2V2G9
SMRiB2V2G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000269931
KOiK06379
OMAiHAYEDKI
OrthoDBiPOG091H0LCB

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00637 Anti_sigma_F, 1 hit
InterProiView protein in InterPro
IPR010194 Anti-sigma_F
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
PANTHERiPTHR35526:SF2 PTHR35526:SF2, 1 hit
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01925 spIIAB, 1 hit

Sequencei

Sequence statusi: Complete.

B2V2G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYENKMNLEF VSKSQNEAFA RVAVAAFIAQ LDPTIDEISD VKTAVSEAVT
60 70 80 90 100
NSIIHGYENK EDGIIKIEVE ICDGEVTIEI TDNGKGIEDI PKVMEPLYTS
110 120 130 140
RPDLERSGMG FTVMETFMDG LLVESEKEKG TRVRMKKKFN ILS
Length:143
Mass (Da):16,013
Last modified:July 1, 2008 - v1
Checksum:i3DA8A1F2D38BC541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA Translation: ACD51891.1
RefSeqiWP_012450152.1, NC_010723.1

Genome annotation databases

EnsemblBacteriaiACD51891; ACD51891; CLH_0842
KEGGicbt:CLH_0842

Similar proteinsi

Entry informationi

Entry nameiSP2AB_CLOBA
AccessioniPrimary (citable) accession number: B2V2G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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