B2V149 (B2V149_CLOBA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase 1 HAMAP MF_00214
Short name=3-dehydroquinase 1 HAMAP MF_00214
EC=4.2.1.10 HAMAP MF_00214

Alternative name(s):
Type I DHQase 1 HAMAP MF_00214

Gene names

Name:	aroD EMBL ACD53421.1
Synonyms:	aroD1 HAMAP MF_00214
Ordered Locus Names:	CLH_0667

Organism

Clostridium botulinum (strain Alaska E43 / Type E3) [Complete proteome] [HAMAP]

Taxonomic identifier

508767 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family. HAMAP MF_00214

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00214
Ligand	Schiff base HAMAP MF_00214 SAAS SAAS018508
Molecular function	Lyase HAMAP MF_00214 EMBL ACD53421.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	144	1	Proton acceptor By similarity HAMAP MF_00214
	Active site	171	1	Schiff-base intermediate with substrate By similarity HAMAP MF_00214

Sequences

	Sequence		Length	Mass (Da)
	B2V149 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 4E278FDE7032851D	FASTA	254	28,391
	10 20 30 40 50 60 MKKTVEVRNL KLGEGIPKIC VPLVGKTNEE ILTEAENLKT LKLDLVEWRV DHYKDVEDIE 70 80 90 100 110 120 KVKEILSKLR ETVKDLPILF TFRSAKEGGE KEVSTEYYAK LNKNIAETGM VDLIDVELFT 130 140 150 160 170 180 GDDVVIDIVD YAHEKNIKVV MSNHDFDKTP NKEEIIKRLC RMQELNADLP KIAVMPQSTT 190 200 210 220 230 240 DVLTLLCATD DMVTKYATRP IITMSMAGLG VISRIAGETF GSALTFGAAK VASAPGQVEV 250 SELHKILKLM HESK

References

[1]	"Complete genome sequence of Clostridium botulinum E3 str. Alaska E43." Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001078 Genomic DNA. Translation: ACD53421.1.
RefSeq	YP_001920062.1. NC_010723.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2V149.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6317333.
GenomeReviews	Gene locus CLH_0667 in contig CP001078_GR.
KEGG	cbt:CLH_0667.
PATRIC	19417596. VBICloBot115804_0596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG732926.
OMA	IAKIAVM.
ProtClustDB	CLSK2322871.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2V149_CLOBA

Accession

Primary (citable) accession number: B2V149

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)