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B2V0I6

- B2V0I6_CLOBA

UniProt

B2V0I6 - B2V0I6_CLOBA

Protein

Alanine racemase

Gene

alr

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCBOT508767:GHKO-1481-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:CLH_1486Imported
    OrganismiClostridium botulinum (strain Alaska E43 / Type E3)Imported
    Taxonomic identifieri508767 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001738: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi508767.CLH_1486.

    Structurei

    3D structure databases

    ProteinModelPortaliB2V0I6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2V0I6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIMRPVWA EIDLDAIAYN MKNIKKLAQN KDVIAVVKAD CYGHGALDVV    50
    PTLLENGASR LAVAVLTEAI ELRNNNVNAP IMILGYTPEY LFEEVVNYDI 100
    EQTVYDLEYA KKLSHLAIKF NKKAKIHIAI DTGMGRIGFI PNEKAIKDIK 150
    EIYDLKGIDV IGIFTHFSTS DETDKEYTNE QFNKFTSFID MLSKVGVKIP 200
    IKHISNSGAI IDLPKTYLDS VRAGIILYGY YPSDEINKDN IKLKPALTLK 250
    ASLTRVQELD INSYISYGKT FKTERKSIIA TLPIGYADGY SRLLAPGAKV 300
    IINGQFAPIV GRICMDQCMI DVTDIDNVNV GDEVIILGED DNLKLTANDL 350
    ANSMGTINYE ILCMLKYRIP RVYIKNGEIF NVRNYL 386
    Length:386
    Mass (Da):43,313
    Last modified:July 1, 2008 - v1
    Checksum:i1A9E6748490BE836
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001078 Genomic DNA. Translation: ACD53922.1.
    RefSeqiYP_001920878.1. NC_010723.1.

    Genome annotation databases

    EnsemblBacteriaiACD53922; ACD53922; CLH_1486.
    GeneIDi6318202.
    KEGGicbt:CLH_1486.
    PATRICi19419238. VBICloBot115804_1416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001078 Genomic DNA. Translation: ACD53922.1 .
    RefSeqi YP_001920878.1. NC_010723.1.

    3D structure databases

    ProteinModelPortali B2V0I6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 508767.CLH_1486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD53922 ; ACD53922 ; CLH_1486 .
    GeneIDi 6318202.
    KEGGi cbt:CLH_1486.
    PATRICi 19419238. VBICloBot115804_1416.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CBOT508767:GHKO-1481-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
      Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Alaska E43 / Type E3Imported.

    Entry informationi

    Entry nameiB2V0I6_CLOBA
    AccessioniPrimary (citable) accession number: B2V0I6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3