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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciCBOT508767:GHKO-552-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:CLH_0556
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Methylglyoxal synthasePRO_1000211978Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000283729.
KOiK01734.
OMAiVYDIPIA.
OrthoDBiEOG644ZN1.

Family and domain databases

Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2V099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIALIAHDK KKQDIIEFAK RNKETLEKYE LLATGTTGKM ISEETGLNIK
60 70 80 90 100
RYLSGPYGGD QQIGGRIAEG TIGLVIFFRD PLTAQPHEPD VSALLRVCDV
110
HNIPVVTNSG TADLIIRQF
Length:119
Mass (Da):13,178
Last modified:July 1, 2008 - v1
Checksum:iDEB529BACED12D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA. Translation: ACD53023.1.
RefSeqiWP_012451021.1. NC_010723.1.

Genome annotation databases

EnsemblBacteriaiACD53023; ACD53023; CLH_0556.
KEGGicbt:CLH_0556.
PATRICi19417380. VBICloBot115804_0488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA. Translation: ACD53023.1.
RefSeqiWP_012451021.1. NC_010723.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD53023; ACD53023; CLH_0556.
KEGGicbt:CLH_0556.
PATRICi19417380. VBICloBot115804_0488.

Phylogenomic databases

HOGENOMiHOG000283729.
KOiK01734.
OMAiVYDIPIA.
OrthoDBiEOG644ZN1.

Enzyme and pathway databases

BioCyciCBOT508767:GHKO-552-MONOMER.

Family and domain databases

Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Alaska E43 / Type E3.

Entry informationi

Entry nameiMGSA_CLOBA
AccessioniPrimary (citable) accession number: B2V099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 1, 2008
Last modified: November 11, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.