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B2UZ17 (G6PI_CLOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CLH_0389
OrganismClostridium botulinum (strain Alaska E43 / Type E3) [Complete proteome] [HAMAP]
Taxonomic identifier508767 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000125707

Sites

Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2UZ17 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 01F2246A20935D47

FASTA44950,384
        10         20         30         40         50         60 
MKKGLTLDLS KTQAFVKDYE LDYMEGMVKD SHDRLHSKTG QGNDFLGWID LPVDYDKEEF 

        70         80         90        100        110        120 
ARIKKAAEKI QSDSDVLVVI GIGGSYLGAR AAIEMLTSNF HNVLDDNKRK VPKIFYAGNN 

       130        140        150        160        170        180 
ISSTYMAELL EAIDGKDVSV NVISKSGTTT EPAIAFRIFK SYLEKKYGVE EARKRIYATT 

       190        200        210        220        230        240 
DKSRGALKSL ADAEGYETFV IPDDVGGRFT VLTPVGLLPI AVAGINIDEM MQGAADARES 

       250        260        270        280        290        300 
YSNPSLKEND CYKYAVTRNA LYNKGKEIEV LVNYEPCIHY FNEWWKQLYG ESEGKDKKGL 

       310        320        330        340        350        360 
FPAAVDFSTD LHSMGQYIQD GRRNLFETVI NVEKARKEIT IEFSEGDLDG LNFLTGKTMD 

       370        380        390        400        410        420 
FVNNKAFQGT LLAHNDGEVP NMVLNVPELS PYYFGHMVYF FEKACGISGY LLGINPFDQP 

       430        440 
GVEAYKKNMF ALLGKPGYED MKDELEKRL

« Hide

References

[1]"Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Alaska E43 / Type E3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001078 Genomic DNA. Translation: ACD53102.1.
RefSeqYP_001919822.1. NC_010723.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2UZ17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6320501.
GenomeReviewsGene locus CLH_0389 in contig CP001078_GR.
KEGGcbt:CLH_0389.
PATRIC19417048. VBICloBot115804_0355.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG615843.
OMAGQGNDFL.
ProtClustDBPRK14097.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CLOBA
AccessionPrimary (citable) accession number: B2UZ17
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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