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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT508767:G1GC0-161-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CLH_0166
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001466761 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiB2UXU5

Structurei

3D structure databases

SMRiB2UXU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2UXU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQE AEMLHIRNIA EKLGLDEEDI EYYGKYKCKI SLDVYNKVKN
60 70 80 90 100
NRDGKLVLVT AINPTPAGEG KSTVTVGLGD ALNKMGKNTV IALREPSLGP
110 120 130 140 150
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL SAAIDNHIHQ
160 170 180 190 200
GNNLRIDSRR IIFKRVMDMN DRALRKIIVG MGGKINGFVR EDGFTITVAS
210 220 230 240 250
EIMAILCLAS DLEDLKHRMG DILIAYDLDG NPVYAKQLEI QGAMALLMKD
260 270 280 290 300
AIKPNLVQTL ENTPALIHGG PFANIAHGCN SIMATKLSLK LGDIVVTEAG
310 320 330 340 350
FGADLGAEKF FDIKCRYGNL KPCCVVIVAT IRALKHHGGV AKADLNIPNV
360 370 380 390 400
EALRLGIANL EKQIENIKKF NVEPVVAINK FVSDSDEEVE FIKEFCEKLG
410 420 430 440 450
VKVALSDVWA KGGDGGIELG EAVLDVIEKD KSSFKTLYKA DNTIEEKILT
460 470 480 490 500
IAKEIYGADG VVYSNEAKKQ IGELVKFNLD KLPICMAKTQ YSLSDNPNLL
510 520 530 540 550
AKPSGFNINV QEIRVSNGAG FIVVQTGNIM TMPGLPKVPA ANKMDVLKDG

EIVGLF
Length:556
Mass (Da):60,263
Last modified:July 1, 2008 - v1
Checksum:i89DA173F6453EE52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA Translation: ACD51878.1
RefSeqiWP_012450144.1, NC_010723.1

Genome annotation databases

EnsemblBacteriaiACD51878; ACD51878; CLH_0166
KEGGicbt:CLH_0166

Entry informationi

Entry nameiFTHS_CLOBA
AccessioniPrimary (citable) accession number: B2UXU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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