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B2UXU5

- FTHS_CLOBA

UniProt

B2UXU5 - FTHS_CLOBA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT508767:GHKO-165-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CLH_0166
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001738: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146676Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi508767.CLH_0166.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UXU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQE AEMLHIRNIA EKLGLDEEDI EYYGKYKCKI SLDVYNKVKN
60 70 80 90 100
NRDGKLVLVT AINPTPAGEG KSTVTVGLGD ALNKMGKNTV IALREPSLGP
110 120 130 140 150
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL SAAIDNHIHQ
160 170 180 190 200
GNNLRIDSRR IIFKRVMDMN DRALRKIIVG MGGKINGFVR EDGFTITVAS
210 220 230 240 250
EIMAILCLAS DLEDLKHRMG DILIAYDLDG NPVYAKQLEI QGAMALLMKD
260 270 280 290 300
AIKPNLVQTL ENTPALIHGG PFANIAHGCN SIMATKLSLK LGDIVVTEAG
310 320 330 340 350
FGADLGAEKF FDIKCRYGNL KPCCVVIVAT IRALKHHGGV AKADLNIPNV
360 370 380 390 400
EALRLGIANL EKQIENIKKF NVEPVVAINK FVSDSDEEVE FIKEFCEKLG
410 420 430 440 450
VKVALSDVWA KGGDGGIELG EAVLDVIEKD KSSFKTLYKA DNTIEEKILT
460 470 480 490 500
IAKEIYGADG VVYSNEAKKQ IGELVKFNLD KLPICMAKTQ YSLSDNPNLL
510 520 530 540 550
AKPSGFNINV QEIRVSNGAG FIVVQTGNIM TMPGLPKVPA ANKMDVLKDG

EIVGLF
Length:556
Mass (Da):60,263
Last modified:July 1, 2008 - v1
Checksum:i89DA173F6453EE52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA. Translation: ACD51878.1.
RefSeqiWP_012450144.1. NC_010723.1.
YP_001919613.1. NC_010723.1.

Genome annotation databases

EnsemblBacteriaiACD51878; ACD51878; CLH_0166.
GeneIDi6318973.
KEGGicbt:CLH_0166.
PATRICi19416610. VBICloBot115804_0147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001078 Genomic DNA. Translation: ACD51878.1 .
RefSeqi WP_012450144.1. NC_010723.1.
YP_001919613.1. NC_010723.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 508767.CLH_0166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD51878 ; ACD51878 ; CLH_0166 .
GeneIDi 6318973.
KEGGi cbt:CLH_0166.
PATRICi 19416610. VBICloBot115804_0147.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CBOT508767:GHKO-165-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Alaska E43 / Type E3.

Entry informationi

Entry nameiFTHS_CLOBA
AccessioniPrimary (citable) accession number: B2UXU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3