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B2UXU5

- FTHS_CLOBA

UniProt

B2UXU5 - FTHS_CLOBA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT508767:GHKO-165-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CLH_0166
    OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
    Taxonomic identifieri508767 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001738: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146676Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi508767.CLH_0166.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2UXU5-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQE AEMLHIRNIA EKLGLDEEDI EYYGKYKCKI SLDVYNKVKN    50
    NRDGKLVLVT AINPTPAGEG KSTVTVGLGD ALNKMGKNTV IALREPSLGP 100
    VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL SAAIDNHIHQ 150
    GNNLRIDSRR IIFKRVMDMN DRALRKIIVG MGGKINGFVR EDGFTITVAS 200
    EIMAILCLAS DLEDLKHRMG DILIAYDLDG NPVYAKQLEI QGAMALLMKD 250
    AIKPNLVQTL ENTPALIHGG PFANIAHGCN SIMATKLSLK LGDIVVTEAG 300
    FGADLGAEKF FDIKCRYGNL KPCCVVIVAT IRALKHHGGV AKADLNIPNV 350
    EALRLGIANL EKQIENIKKF NVEPVVAINK FVSDSDEEVE FIKEFCEKLG 400
    VKVALSDVWA KGGDGGIELG EAVLDVIEKD KSSFKTLYKA DNTIEEKILT 450
    IAKEIYGADG VVYSNEAKKQ IGELVKFNLD KLPICMAKTQ YSLSDNPNLL 500
    AKPSGFNINV QEIRVSNGAG FIVVQTGNIM TMPGLPKVPA ANKMDVLKDG 550
    EIVGLF 556
    Length:556
    Mass (Da):60,263
    Last modified:July 1, 2008 - v1
    Checksum:i89DA173F6453EE52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001078 Genomic DNA. Translation: ACD51878.1.
    RefSeqiYP_001919613.1. NC_010723.1.

    Genome annotation databases

    EnsemblBacteriaiACD51878; ACD51878; CLH_0166.
    GeneIDi6318973.
    KEGGicbt:CLH_0166.
    PATRICi19416610. VBICloBot115804_0147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001078 Genomic DNA. Translation: ACD51878.1 .
    RefSeqi YP_001919613.1. NC_010723.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 508767.CLH_0166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD51878 ; ACD51878 ; CLH_0166 .
    GeneIDi 6318973.
    KEGGi cbt:CLH_0166.
    PATRICi 19416610. VBICloBot115804_0147.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CBOT508767:GHKO-165-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
      Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Alaska E43 / Type E3.

    Entry informationi

    Entry nameiFTHS_CLOBA
    AccessioniPrimary (citable) accession number: B2UXU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3