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B2UW74

- SYR_CLOBA

UniProt

B2UW74 - SYR_CLOBA

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT508767:GHKO-2320-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
    Alternative name(s):
    Arginyl-tRNA synthetaseUniRule annotation
    Short name:
    ArgRSUniRule annotation
    Gene namesi
    Name:argSUniRule annotation
    Ordered Locus Names:CLH_2328
    OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
    Taxonomic identifieri508767 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001738: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Arginine--tRNA ligasePRO_1000095351Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi508767.CLH_2328.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UW74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 13011"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247211.
    KOiK01887.
    OMAiYVKFHDE.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2UW74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYKNKIAQL IKQHVDLDID AIEKLIEIPP KSEMGDYAFP CFQLSKVMRK    50
    APNMIAETLK DAINKDGFER IENLGPYLNF FVDKGVFAEN TINKILKDGD 100
    SYGESNIGEG KTVCVEYSSP NIAKPFHVGH LFTTAIGNSL YKMFKKEGYD 150
    VVGLNHLGDW GTQFGKLISA YNRWVDEEAL EKAPIDELLR IYVKFHDEAE 200
    KDPSLEDEGR MYFKKLETGD AEAQALWKRF RDLSLKEFER VYDILGVKFD 250
    SLAGEAFYND KMDVVVNELK DKGLLVESNG AQVVMLDDYN MPPCIVLKGD 300
    GASIYATRDL AAAMYRKKTY DFYKSIYVVG SPQALHFKQV FKVLELAGHE 350
    WANDCVHVGF GLVKFADRKL STRKGEVVLL DDLIRESVEK TLEVINEKNP 400
    ELENKEEVAK KIGVGAIIFT YLKNSREKDI VFDWKEILSF EGETGPYVQY 450
    SYARANSIIS RAENISSEVD YSKLSSKEEF ELVKVLANFN NQIKLATDKL 500
    EPSILTRYVI DVAKSFNKFY NAHSVLNLDD EVLKATRLSL VKSSLQVIKN 550
    GLELLGIDVV EKM 563
    Length:563
    Mass (Da):63,923
    Last modified:July 1, 2008 - v1
    Checksum:iB6A4D37B982036FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001078 Genomic DNA. Translation: ACD52170.1.
    RefSeqiYP_001921709.1. NC_010723.1.

    Genome annotation databases

    EnsemblBacteriaiACD52170; ACD52170; CLH_2328.
    GeneIDi6318837.
    KEGGicbt:CLH_2328.
    PATRICi19420913. VBICloBot115804_2248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001078 Genomic DNA. Translation: ACD52170.1 .
    RefSeqi YP_001921709.1. NC_010723.1.

    3D structure databases

    ProteinModelPortali B2UW74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 508767.CLH_2328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD52170 ; ACD52170 ; CLH_2328 .
    GeneIDi 6318837.
    KEGGi cbt:CLH_2328.
    PATRICi 19420913. VBICloBot115804_2248.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247211.
    KOi K01887.
    OMAi YVKFHDE.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci CBOT508767:GHKO-2320-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
      Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Alaska E43 / Type E3.

    Entry informationi

    Entry nameiSYR_CLOBA
    AccessioniPrimary (citable) accession number: B2UW74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3