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B2UW74

- SYR_CLOBA

UniProt

B2UW74 - SYR_CLOBA

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT508767:GHKO-2320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:CLH_2328
OrganismiClostridium botulinum (strain Alaska E43 / Type E3)
Taxonomic identifieri508767 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001738: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Arginine--tRNA ligasePRO_1000095351Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi508767.CLH_2328.

Structurei

3D structure databases

ProteinModelPortaliB2UW74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 13011"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiYVKFHDE.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UW74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYKNKIAQL IKQHVDLDID AIEKLIEIPP KSEMGDYAFP CFQLSKVMRK
60 70 80 90 100
APNMIAETLK DAINKDGFER IENLGPYLNF FVDKGVFAEN TINKILKDGD
110 120 130 140 150
SYGESNIGEG KTVCVEYSSP NIAKPFHVGH LFTTAIGNSL YKMFKKEGYD
160 170 180 190 200
VVGLNHLGDW GTQFGKLISA YNRWVDEEAL EKAPIDELLR IYVKFHDEAE
210 220 230 240 250
KDPSLEDEGR MYFKKLETGD AEAQALWKRF RDLSLKEFER VYDILGVKFD
260 270 280 290 300
SLAGEAFYND KMDVVVNELK DKGLLVESNG AQVVMLDDYN MPPCIVLKGD
310 320 330 340 350
GASIYATRDL AAAMYRKKTY DFYKSIYVVG SPQALHFKQV FKVLELAGHE
360 370 380 390 400
WANDCVHVGF GLVKFADRKL STRKGEVVLL DDLIRESVEK TLEVINEKNP
410 420 430 440 450
ELENKEEVAK KIGVGAIIFT YLKNSREKDI VFDWKEILSF EGETGPYVQY
460 470 480 490 500
SYARANSIIS RAENISSEVD YSKLSSKEEF ELVKVLANFN NQIKLATDKL
510 520 530 540 550
EPSILTRYVI DVAKSFNKFY NAHSVLNLDD EVLKATRLSL VKSSLQVIKN
560
GLELLGIDVV EKM
Length:563
Mass (Da):63,923
Last modified:July 1, 2008 - v1
Checksum:iB6A4D37B982036FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001078 Genomic DNA. Translation: ACD52170.1.
RefSeqiYP_001921709.1. NC_010723.1.

Genome annotation databases

EnsemblBacteriaiACD52170; ACD52170; CLH_2328.
GeneIDi6318837.
KEGGicbt:CLH_2328.
PATRICi19420913. VBICloBot115804_2248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001078 Genomic DNA. Translation: ACD52170.1 .
RefSeqi YP_001921709.1. NC_010723.1.

3D structure databases

ProteinModelPortali B2UW74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 508767.CLH_2328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD52170 ; ACD52170 ; CLH_2328 .
GeneIDi 6318837.
KEGGi cbt:CLH_2328.
PATRICi 19420913. VBICloBot115804_2248.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247211.
KOi K01887.
OMAi YVKFHDE.
OrthoDBi EOG6JB13C.

Enzyme and pathway databases

BioCyci CBOT508767:GHKO-2320-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43."
    Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Alaska E43 / Type E3.

Entry informationi

Entry nameiSYR_CLOBA
AccessioniPrimary (citable) accession number: B2UW74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3