B2UW73 (GLMM_HELPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	HPSH_00365

Organism

Helicobacter pylori (strain Shi470) [Complete proteome] [HAMAP]

Taxonomic identifier

512562 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000201108
Sites
	Active site	99	1	Phosphoserine intermediate By similarity
	Metal binding	99	1	Magnesium; via phosphate group By similarity
	Metal binding	242	1	Magnesium By similarity
	Metal binding	244	1	Magnesium By similarity
	Metal binding	246	1	Magnesium By similarity
Amino acid modifications
	Modified residue	99	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2UW73 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 7BEA83C99B50EAE9	FASTA	445	49,144
	10 20 30 40 50 60 MKIFGTDGVR GKAGVKLTPM FVMRLGIAAG LYFKKHSKTN KILIGKDTRK SGYMVENALV 70 80 90 100 110 120 SALTSIGYNV IQIGPMPTPA IAFLTEDMRC DAGIMISASH NPFEDNGIKF FNSYGYKLKE 130 140 150 160 170 180 EEEKAIEEIF HDEELLHSSY KVGESVGSAK RIDDVIGRYI VHLKHSFPKH LNLQSLRIVL 190 200 210 220 230 240 DTANGAAYKV APVVFSELGA DVLVINDEPN GCNINEQCGA LHPNQLSQEV KKYRADLGFA 250 260 270 280 290 300 FDGDADRLVV VDNLGNIVHG DKLLGVLGVY QKSKNALSSQ AIVATSMSNL ALKEYLKSQD 310 320 330 340 350 360 LELKHCAIGD KFVSECMQLN KANFGGEQSG HIIFSDYAKT GDGLVCALQV SALVLESKQV 370 380 390 400 410 420 SSVALNPFEL YPQSLINLNI QKKPPLESLK GYSALLKELD KLEIRHLIRY SGTENKLRIL 430 440 LEAKDEKLLE SKMQELKEFF EGHLC

References

[1]	"Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans." Kersulyte D., Kalia A., Gilman R.H., Berg D.E. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Shi470.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001072 Genomic DNA. Translation: ACD47538.1.
RefSeq	YP_001909568.1. NC_010698.2.
3D structure databases
ProteinModelPortal	B2UW73.
ModBase	Search...
Protein-protein interaction databases
STRING	B2UW73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6296244.
GenomeReviews	Gene locus HPSH_00365 in contig CP001072_GR.
KEGG	hps:HPSH_00365.
PATRIC	20611503. VBIHelPyl23559_0070.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644964.
OMA	CANGPSA.
ProtClustDB	PRK14324.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_HELPS

Accession

Primary (citable) accession number: B2UW73

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program