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B2UW72

- LSPA_HELPS

UniProt

B2UW72 - LSPA_HELPS

Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

    Catalytic activityi

    Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051UniRule annotation
    Active sitei131 – 1311UniRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciHPYL512562:GHHZ-76-MONOMER.
    UniPathwayiUPA00665.

    Protein family/group databases

    MEROPSiA08.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
    Alternative name(s):
    Prolipoprotein signal peptidaseUniRule annotation
    Signal peptidase IIUniRule annotation
    Short name:
    SPase IIUniRule annotation
    Gene namesi
    Name:lspAUniRule annotation
    Ordered Locus Names:HPSH_00360
    OrganismiHelicobacter pylori (strain Shi470)
    Taxonomic identifieri512562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008831: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Lipoprotein signal peptidasePRO_1000097259Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi512562.HPSH_00360.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalUniRule annotationAdd
    BLAST
    Transmembranei58 – 7821HelicalUniRule annotationAdd
    BLAST
    Transmembranei84 – 10421HelicalUniRule annotationAdd
    BLAST
    Transmembranei122 – 14221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0597.
    HOGENOMiHOG000096992.
    KOiK03101.
    OMAiKNHAIEF.
    OrthoDBiEOG686NMZ.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2UW72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKTTQKSLL IFIVVFSLIF GTDQAIKYAI LEGFRYESLI IDIVLVFNKG    50
    VAFSLLSFLE GGLKYLQILL ILGLFIFLMC QKELFKNHAI EFGMVFGAGV 100
    SNVLDRFVHG GVVDYVYYHY GFDFAIFNFA DVMIDVGVGV LLLRQFFFKQ 150
    KQNKIKA 157
    Length:157
    Mass (Da):17,906
    Last modified:July 1, 2008 - v1
    Checksum:iCEB534159D5C0E88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001072 Genomic DNA. Translation: ACD47537.1.
    RefSeqiWP_000921400.1. NC_010698.2.
    YP_001909567.1. NC_010698.2.

    Genome annotation databases

    EnsemblBacteriaiACD47537; ACD47537; HPSH_00360.
    GeneIDi6296079.
    KEGGihps:HPSH_00360.
    PATRICi20611501. VBIHelPyl23559_0069.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001072 Genomic DNA. Translation: ACD47537.1 .
    RefSeqi WP_000921400.1. NC_010698.2.
    YP_001909567.1. NC_010698.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 512562.HPSH_00360.

    Protein family/group databases

    MEROPSi A08.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD47537 ; ACD47537 ; HPSH_00360 .
    GeneIDi 6296079.
    KEGGi hps:HPSH_00360.
    PATRICi 20611501. VBIHelPyl23559_0069.

    Phylogenomic databases

    eggNOGi COG0597.
    HOGENOMi HOG000096992.
    KOi K03101.
    OMAi KNHAIEF.
    OrthoDBi EOG686NMZ.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci HPYL512562:GHHZ-76-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
      Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Shi470.

    Entry informationi

    Entry nameiLSPA_HELPS
    AccessioniPrimary (citable) accession number: B2UW72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3