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B2UW72

- LSPA_HELPS

UniProt

B2UW72 - LSPA_HELPS

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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051UniRule annotation
Active sitei131 – 1311UniRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciHPYL512562:GHHZ-76-MONOMER.
UniPathwayiUPA00665.

Protein family/group databases

MEROPSiA08.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:HPSH_00360
OrganismiHelicobacter pylori (strain Shi470)
Taxonomic identifieri512562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008831: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Lipoprotein signal peptidasePRO_1000097259Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi512562.HPSH_00360.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalUniRule annotationAdd
BLAST
Transmembranei58 – 7821HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei122 – 14221HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096992.
KOiK03101.
OMAiKNHAIEF.
OrthoDBiEOG686NMZ.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UW72 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKTTQKSLL IFIVVFSLIF GTDQAIKYAI LEGFRYESLI IDIVLVFNKG
60 70 80 90 100
VAFSLLSFLE GGLKYLQILL ILGLFIFLMC QKELFKNHAI EFGMVFGAGV
110 120 130 140 150
SNVLDRFVHG GVVDYVYYHY GFDFAIFNFA DVMIDVGVGV LLLRQFFFKQ

KQNKIKA
Length:157
Mass (Da):17,906
Last modified:July 1, 2008 - v1
Checksum:iCEB534159D5C0E88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001072 Genomic DNA. Translation: ACD47537.1.
RefSeqiWP_000921400.1. NC_010698.2.
YP_001909567.1. NC_010698.2.

Genome annotation databases

EnsemblBacteriaiACD47537; ACD47537; HPSH_00360.
GeneIDi6296079.
KEGGihps:HPSH_00360.
PATRICi20611501. VBIHelPyl23559_0069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001072 Genomic DNA. Translation: ACD47537.1 .
RefSeqi WP_000921400.1. NC_010698.2.
YP_001909567.1. NC_010698.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 512562.HPSH_00360.

Protein family/group databases

MEROPSi A08.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD47537 ; ACD47537 ; HPSH_00360 .
GeneIDi 6296079.
KEGGi hps:HPSH_00360.
PATRICi 20611501. VBIHelPyl23559_0069.

Phylogenomic databases

eggNOGi COG0597.
HOGENOMi HOG000096992.
KOi K03101.
OMAi KNHAIEF.
OrthoDBi EOG686NMZ.

Enzyme and pathway databases

UniPathwayi UPA00665 .
BioCyci HPYL512562:GHHZ-76-MONOMER.

Family and domain databases

HAMAPi MF_00161. LspA.
InterProi IPR001872. Peptidase_A8.
[Graphical view ]
Pfami PF01252. Peptidase_A8. 1 hit.
[Graphical view ]
PRINTSi PR00781. LIPOSIGPTASE.
TIGRFAMsi TIGR00077. lspA. 1 hit.
PROSITEi PS00855. SPASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
    Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Shi470.

Entry informationi

Entry nameiLSPA_HELPS
AccessioniPrimary (citable) accession number: B2UW72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3