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Protein

NAD kinase

Gene

nadK

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton acceptorUniRule annotation1
Binding sitei167NADUniRule annotation1
Binding sitei169NADUniRule annotation1
Binding sitei177NAD; via carbonyl oxygenUniRule annotation1
Binding sitei236NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 71NADUniRule annotation2
Nucleotide bindingi139 – 140NADUniRule annotation2
Nucleotide bindingi180 – 185NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL512562:G1GBY-1518-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:HPSH_07935
OrganismiHelicobacter pylori (strain Shi470)
Taxonomic identifieri512562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208681 – 284NAD kinaseAdd BLAST284

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B2UVU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSHQTIGV FVRPTHYQNP LFEKLERAKE WVLKLLEDEG FESFMIDGLD
60 70 80 90 100
GAKDERLIEK AYAFLCLGGD GTILGALRMT HSYNKPCFGV RIGNLGFLSA
110 120 130 140 150
VELNGLKGFL QDLKQDKIKL EEHLALEGRI GKTSFYAINE IVIAKKKALG
160 170 180 190 200
VLDIQAYVGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL
210 220 230 240 250
TPLCDFSLTQ RPLVLGAEFC LNFCAHEDAL VVIDGQATYD LKANQPLYIQ
260 270 280
KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP SKKR
Length:284
Mass (Da):31,668
Last modified:July 1, 2008 - v1
Checksum:iCA1929A7757D9522
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001072 Genomic DNA Translation: ACD48972.1
RefSeqiWP_012443454.1, NC_010698.2

Genome annotation databases

EnsemblBacteriaiACD48972; ACD48972; HPSH_07935
KEGGihps:HPSH_07935

Similar proteinsi

Entry informationi

Entry nameiNADK_HELPS
AccessioniPrimary (citable) accession number: B2UVU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health