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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:HPSH_04450
OrganismiHelicobacter pylori (strain Shi470)
Taxonomic identifieri512562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalUniRule annotationAdd BLAST21
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Transmembranei88 – 108HelicalUniRule annotationAdd BLAST21
Transmembranei129 – 149HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei330 – 350HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906321 – 353Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST353

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UTZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSLLYGYF NINLFQYLTF RAGLGFFIAF FLTLFLMPKF ILWAKAKKAN
60 70 80 90 100
QPISSFVPSH QNKKDTPTMG GIVFVFATIV ASVLCASLGN LYVLLGMIVL
110 120 130 140 150
VGFSFVGFKD DYTKINQQNN AGMSVKMKFG MLFVLSLVVS VLLSLKGLDT
160 170 180 190 200
FLYAPFLKNP LFEMPTILAV GFWVLVFLST SNAVNLTDGL DGLASVPSIF
210 220 230 240 250
TLLSLSIFVY VAGNAEFSKY LLYPKVIDVG ELFVISLALV GSLFGFLWYN
260 270 280 290 300
CNPASVFMGD SGSLALGGFI AYNAIVSHNE ILLVLMGLIF VVETLSVILQ
310 320 330 340 350
VGSYKTRKKR LFLMAPIHHH FEQKGWAENK VIVRFWIISM LSNLVALLSL

KVR
Length:353
Mass (Da):39,195
Last modified:July 1, 2008 - v1
Checksum:iCB45CC86CF22D121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001072 Genomic DNA. Translation: ACD48325.1.
RefSeqiWP_000967133.1. NC_010698.2.

Genome annotation databases

EnsemblBacteriaiACD48325; ACD48325; HPSH_04450.
KEGGihps:HPSH_04450.

Similar proteinsi

Entry informationi

Entry nameiMRAY_HELPS
AccessioniPrimary (citable) accession number: B2UTZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families