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B2UTQ8

- AMPA_HELPS

UniProt

B2UTQ8 - AMPA_HELPS

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Protein
Probable cytosol aminopeptidase
Gene
pepA, HPSH_04025
Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Manganese 2 By similarity
Metal bindingi263 – 2631Manganese 1 By similarity
Metal bindingi263 – 2631Manganese 2 By similarity
Active sitei270 – 2701 Reviewed prediction
Metal bindingi281 – 2811Manganese 2 By similarity
Metal bindingi340 – 3401Manganese 1 By similarity
Metal bindingi342 – 3421Manganese 1 By similarity
Metal bindingi342 – 3421Manganese 2 By similarity
Active sitei344 – 3441 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHPYL512562:GHHZ-800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:HPSH_04025
OrganismiHelicobacter pylori (strain Shi470)
Taxonomic identifieri512562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008831: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable cytosol aminopeptidaseUniRule annotation
PRO_1000098326Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi512562.HPSH_04025.

Structurei

3D structure databases

ProteinModelPortaliB2UTQ8.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiARACEDN.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UTQ8-1 [UniParc]FASTAAdd to Basket

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MLKIKLEKTT FENAKAECGL VFIINKDFDH AWVKNKKLLE TFKYEGEGVF    50
LDQENKILYA GVKEDDVHLL RESACLAVRT LKKLAFKSVK VGVYTCDTHS 100
KDNALLENLK ALFLGLKLGL YEYDTFKSNK KESVLKEAIV ALELHKPCEK 150
TCANSLEKSA KEALKYAEIM TESLNIVRDL VNTPPMIATP VYMAEVAQKV 200
AKENHLEIHV HDEKFLEEKK MNAFLAVNKA SLGVNPPRLI HLVYKPKKAK 250
KKIALVGKGL TYDCGGLSLK PADYMVTMKA DKGGGSAVIG LLNALAKLGV 300
EAEVHGIIGA TENMIGPAAY KPDDILISKE GKSIEVRNTD AEGRLVLADC 350
LSYAQDLSPD VIVDFATLTG ACVVGLGEFT SAIMGHNEEL KNLFETSGLE 400
SGELLAKLPF NRHLKKLIES KIADVCNISS SRYGGAITAG LFLNEFIRDE 450
FKDKWLHIDI AGPAYVEKEW DVNSFGASGA GVRACTAFVE EFLKKA 496
Length:496
Mass (Da):54,537
Last modified:July 1, 2008 - v1
Checksum:iA70A431A569912CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001072 Genomic DNA. Translation: ACD48240.1.
RefSeqiWP_000912817.1. NC_010698.2.
YP_001910270.1. NC_010698.2.

Genome annotation databases

EnsemblBacteriaiACD48240; ACD48240; HPSH_04025.
GeneIDi6297595.
KEGGihps:HPSH_04025.
PATRICi20612965. VBIHelPyl23559_0794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001072 Genomic DNA. Translation: ACD48240.1 .
RefSeqi WP_000912817.1. NC_010698.2.
YP_001910270.1. NC_010698.2.

3D structure databases

ProteinModelPortali B2UTQ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 512562.HPSH_04025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD48240 ; ACD48240 ; HPSH_04025 .
GeneIDi 6297595.
KEGGi hps:HPSH_04025.
PATRICi 20612965. VBIHelPyl23559_0794.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi ARACEDN.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci HPYL512562:GHHZ-800-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
    Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Shi470.

Entry informationi

Entry nameiAMPA_HELPS
AccessioniPrimary (citable) accession number: B2UTQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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