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B2UTQ8

- AMPA_HELPS

UniProt

B2UTQ8 - AMPA_HELPS

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi258 – 2581Manganese 2UniRule annotation
    Metal bindingi263 – 2631Manganese 1UniRule annotation
    Metal bindingi263 – 2631Manganese 2UniRule annotation
    Active sitei270 – 2701UniRule annotation
    Metal bindingi281 – 2811Manganese 2UniRule annotation
    Metal bindingi340 – 3401Manganese 1UniRule annotation
    Metal bindingi342 – 3421Manganese 1UniRule annotation
    Metal bindingi342 – 3421Manganese 2UniRule annotation
    Active sitei344 – 3441UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciHPYL512562:GHHZ-800-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
    Short name:
    LAPUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:HPSH_04025
    OrganismiHelicobacter pylori (strain Shi470)
    Taxonomic identifieri512562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008831: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Probable cytosol aminopeptidasePRO_1000098326Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi512562.HPSH_04025.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UTQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243129.
    KOiK01255.
    OMAiARACEDN.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2UTQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIKLEKTT FENAKAECGL VFIINKDFDH AWVKNKKLLE TFKYEGEGVF    50
    LDQENKILYA GVKEDDVHLL RESACLAVRT LKKLAFKSVK VGVYTCDTHS 100
    KDNALLENLK ALFLGLKLGL YEYDTFKSNK KESVLKEAIV ALELHKPCEK 150
    TCANSLEKSA KEALKYAEIM TESLNIVRDL VNTPPMIATP VYMAEVAQKV 200
    AKENHLEIHV HDEKFLEEKK MNAFLAVNKA SLGVNPPRLI HLVYKPKKAK 250
    KKIALVGKGL TYDCGGLSLK PADYMVTMKA DKGGGSAVIG LLNALAKLGV 300
    EAEVHGIIGA TENMIGPAAY KPDDILISKE GKSIEVRNTD AEGRLVLADC 350
    LSYAQDLSPD VIVDFATLTG ACVVGLGEFT SAIMGHNEEL KNLFETSGLE 400
    SGELLAKLPF NRHLKKLIES KIADVCNISS SRYGGAITAG LFLNEFIRDE 450
    FKDKWLHIDI AGPAYVEKEW DVNSFGASGA GVRACTAFVE EFLKKA 496
    Length:496
    Mass (Da):54,537
    Last modified:July 1, 2008 - v1
    Checksum:iA70A431A569912CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001072 Genomic DNA. Translation: ACD48240.1.
    RefSeqiWP_000912817.1. NC_010698.2.
    YP_001910270.1. NC_010698.2.

    Genome annotation databases

    EnsemblBacteriaiACD48240; ACD48240; HPSH_04025.
    GeneIDi6297595.
    KEGGihps:HPSH_04025.
    PATRICi20612965. VBIHelPyl23559_0794.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001072 Genomic DNA. Translation: ACD48240.1 .
    RefSeqi WP_000912817.1. NC_010698.2.
    YP_001910270.1. NC_010698.2.

    3D structure databases

    ProteinModelPortali B2UTQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 512562.HPSH_04025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD48240 ; ACD48240 ; HPSH_04025 .
    GeneIDi 6297595.
    KEGGi hps:HPSH_04025.
    PATRICi 20612965. VBIHelPyl23559_0794.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243129.
    KOi K01255.
    OMAi ARACEDN.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci HPYL512562:GHHZ-800-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
      Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Shi470.

    Entry informationi

    Entry nameiAMPA_HELPS
    AccessioniPrimary (citable) accession number: B2UTQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3