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B2UTQ8

- AMPA_HELPS

UniProt

B2UTQ8 - AMPA_HELPS

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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Manganese 2UniRule annotation
Metal bindingi263 – 2631Manganese 1UniRule annotation
Metal bindingi263 – 2631Manganese 2UniRule annotation
Active sitei270 – 2701UniRule annotation
Metal bindingi281 – 2811Manganese 2UniRule annotation
Metal bindingi340 – 3401Manganese 1UniRule annotation
Metal bindingi342 – 3421Manganese 1UniRule annotation
Metal bindingi342 – 3421Manganese 2UniRule annotation
Active sitei344 – 3441UniRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHPYL512562:GHHZ-800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:HPSH_04025
OrganismiHelicobacter pylori (strain Shi470)
Taxonomic identifieri512562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008831: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable cytosol aminopeptidasePRO_1000098326Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi512562.HPSH_04025.

Structurei

3D structure databases

ProteinModelPortaliB2UTQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243129.
KOiK01255.
OMAiARACEDN.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UTQ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKIKLEKTT FENAKAECGL VFIINKDFDH AWVKNKKLLE TFKYEGEGVF
60 70 80 90 100
LDQENKILYA GVKEDDVHLL RESACLAVRT LKKLAFKSVK VGVYTCDTHS
110 120 130 140 150
KDNALLENLK ALFLGLKLGL YEYDTFKSNK KESVLKEAIV ALELHKPCEK
160 170 180 190 200
TCANSLEKSA KEALKYAEIM TESLNIVRDL VNTPPMIATP VYMAEVAQKV
210 220 230 240 250
AKENHLEIHV HDEKFLEEKK MNAFLAVNKA SLGVNPPRLI HLVYKPKKAK
260 270 280 290 300
KKIALVGKGL TYDCGGLSLK PADYMVTMKA DKGGGSAVIG LLNALAKLGV
310 320 330 340 350
EAEVHGIIGA TENMIGPAAY KPDDILISKE GKSIEVRNTD AEGRLVLADC
360 370 380 390 400
LSYAQDLSPD VIVDFATLTG ACVVGLGEFT SAIMGHNEEL KNLFETSGLE
410 420 430 440 450
SGELLAKLPF NRHLKKLIES KIADVCNISS SRYGGAITAG LFLNEFIRDE
460 470 480 490
FKDKWLHIDI AGPAYVEKEW DVNSFGASGA GVRACTAFVE EFLKKA
Length:496
Mass (Da):54,537
Last modified:July 1, 2008 - v1
Checksum:iA70A431A569912CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001072 Genomic DNA. Translation: ACD48240.1.
RefSeqiWP_000912817.1. NC_010698.2.
YP_001910270.1. NC_010698.2.

Genome annotation databases

EnsemblBacteriaiACD48240; ACD48240; HPSH_04025.
GeneIDi6297595.
KEGGihps:HPSH_04025.
PATRICi20612965. VBIHelPyl23559_0794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001072 Genomic DNA. Translation: ACD48240.1 .
RefSeqi WP_000912817.1. NC_010698.2.
YP_001910270.1. NC_010698.2.

3D structure databases

ProteinModelPortali B2UTQ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 512562.HPSH_04025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD48240 ; ACD48240 ; HPSH_04025 .
GeneIDi 6297595.
KEGGi hps:HPSH_04025.
PATRICi 20612965. VBIHelPyl23559_0794.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243129.
KOi K01255.
OMAi ARACEDN.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci HPYL512562:GHHZ-800-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
    Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Shi470.

Entry informationi

Entry nameiAMPA_HELPS
AccessioniPrimary (citable) accession number: B2UTQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3