B2UTK9 (KAD_HELPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	HPSH_03780

Organism

Helicobacter pylori (strain Shi470) [Complete proteome] [HAMAP]

Taxonomic identifier

512562 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Adenylate kinase HAMAP MF_00235		PRO_1000100571
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity
	Nucleotide binding	35 – 63	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2UTK9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: D2FF847311CD546F	FASTA	191	21,369
	10 20 30 40 50 60 MKQLFLIIGA PGSGKTTDAE LIAKNNSEKI AHFSTGDLLR AESAKKTERG LLIEKFTSQG 70 80 90 100 110 120 ELVPLEIVVE TILSAIKSSD KGIILIDGYP RSVEQMQALD KELSAQNEVV LKSVIEVEVS 130 140 150 160 170 180 ENTAKERVLG RSRGADDNEM VFHNRMRVFL DPLGEIQNFY KNKKVYKAIN GERSIEEIVH 190 EMQEYILSFG N

References

[1]	"Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans." Kersulyte D., Kalia A., Gilman R.H., Berg D.E. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Shi470.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001072 Genomic DNA. Translation: ACD48191.1.
RefSeq	YP_001910221.1. NC_010698.2.
3D structure databases
ProteinModelPortal	B2UTK9.
ModBase	Search...
Protein-protein interaction databases
STRING	B2UTK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6296256.
GenomeReviews	Gene locus HPSH_03780 in contig CP001072_GR.
KEGG	hps:HPSH_03780.
PATRIC	20612867. VBIHelPyl23559_0745.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630208.
OMA	EMQKYIL.
ProtClustDB	PRK00279.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR000850. Adenylate_kin. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_HELPS

Accession

Primary (citable) accession number: B2UTK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program