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B2UTC7 (B2UTC7_HELPS) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897
Ordered Locus Names:HPSH_03350
OrganismHelicobacter pylori (strain Shi470) [Complete proteome] [HAMAP]
Taxonomic identifier512562 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length826 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
B2UTC7 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: E9F5BC6B4E4532D3

FASTA82692,812
        10         20         30         40         50         60 
MQDNLINETK NIVEVGIDSS IEESYLAYSM SVIIGRALPD ARDGLKPVHR RILYAMHELG 

        70         80         90        100        110        120 
LTSKVAYKKS ARIVGDVIGK YHPHGDNAVY DALVRMAQDF SMRLELVDGQ GNFGSIDGDN 

       130        140        150        160        170        180 
AAAMRYTEAR MTKASEEILR DIDKDTIDFV PNYDDTLKEP DILPSRLPNL LVNGANGIAV 

       190        200        210        220        230        240 
GMATSIPPHR IDEIIDALVH VLENPNAGLD EILEFVKGPD FPTGGIIYGK AGIIEAYKTG 

       250        260        270        280        290        300 
RGRVKVRAKV HVEKTKNKEI IVLDEMPFQT NKAKLVEQIS DLAREKQIEG ISEVRDESDR 

       310        320        330        340        350        360 
EGIRVVIELK RDAMSEIVLN HLYKLTTMET TFSIILLAIY NKEPKIFTLL ELLRLFLNHR 

       370        380        390        400        410        420 
KTIIIRRTIF ELEKAKARAH ILEGYLIALD NIDEIVRLIK TSQSPEAAKD ALMERFTLSE 

       430        440        450        460        470        480 
IQSKAILEMR LQRLTGLERD KIKEEYQNLL ELISDLNGIL KSEDRLNEVV KTELLEVKEQ 

       490        500        510        520        530        540 
FSSQRCTEIQ EVYENIDIED LIANEPMVVS MSYKGYVKRV DLKAYERQNR GGKGKLSGNT 

       550        560        570        580        590        600 
YEDDFIENFF VANTHDILLF ITNKGQLYRL KVYKIPEASR IAMGKAIVNL ISLAPDEKIM 

       610        620        630        640        650        660 
ATLSTKDFSD ERSLAFFTKK GVVKRTNLSE FDSNYNGMRA IVLDEGDELV SAKIVDKNAK 

       670        680        690        700        710        720 
HLLIASYLGI FIKFSLEDVR EIGRTTRGVR GIRLNENDFV VGAVVISDDS NKLLSVSENG 

       730        740        750        760        770        780 
LGKQTLAEAY REQSRGGKGI IGMKLTQKTG NLVSVISVDD ENLDLMILTA SAKMIRVSIQ 

       790        800        810        820 
DIKETIGRNT SGVKLIDTAD KVVYANSCPK EEEPENSENP PTQLFE

« Hide

References

[1]"Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001072 Genomic DNA. Translation: ACD48109.1.
RefSeqYP_001910139.1. NC_010698.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2UTC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6296014.
GenomeReviewsGene locus HPSH_03350 in contig CP001072_GR.
KEGGhps:HPSH_03350.
PATRIC20612695. VBIHelPyl23559_0659.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG635183.
OMATSIPPHR.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2UTC7_HELPS
AccessionPrimary (citable) accession number: B2UTC7
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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