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B2USY3

- THIM_HELPS

UniProt

B2USY3 - THIM_HELPS

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Helicobacter pylori (strain Shi470)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371Substrate; via amide nitrogenUniRule annotation
    Binding sitei113 – 1131ATPUniRule annotation
    Binding sitei158 – 1581ATPUniRule annotation
    Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL512562:GHHZ-516-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:HPSH_02575
    OrganismiHelicobacter pylori (strain Shi470)
    Taxonomic identifieri512562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008831: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Hydroxyethylthiazole kinasePRO_0000383866Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi512562.HPSH_02575.

    Structurei

    3D structure databases

    ProteinModelPortaliB2USY3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiNACTQLA.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2USY3-1 [UniParc]FASTAAdd to Basket

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    MLKELRQKRP LVHNITNYVV AQFVANGLLA LGASPLMSDA IAEMQDLAKI    50
    SDALAINIGT LNERTILCAK EAIKHYKALN KPIVLDPVGC SASALRHGTS 100
    LELLESEGIS VLRGNAAELG SLVGISCGSK GLDSHYATTP IEIVKLVAQK 150
    YSVIAVMTGK TDYVSDGKKV FSITGGSEYL ALITGAGCLH AAACASFLSL 200
    RKDPLDSMAQ LCALYKQAAF NAQKKVSENN GSNGSFLFYF LDALSLPIKL 250
    ENSLIKEEL 259
    Length:259
    Mass (Da):27,577
    Last modified:July 1, 2008 - v1
    Checksum:i4DED706A8A242511
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001072 Genomic DNA. Translation: ACD47965.1.
    RefSeqiWP_000910638.1. NC_010698.2.
    YP_001909995.1. NC_010698.2.

    Genome annotation databases

    EnsemblBacteriaiACD47965; ACD47965; HPSH_02575.
    GeneIDi6296306.
    KEGGihps:HPSH_02575.
    PATRICi20612379. VBIHelPyl23559_0502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001072 Genomic DNA. Translation: ACD47965.1 .
    RefSeqi WP_000910638.1. NC_010698.2.
    YP_001909995.1. NC_010698.2.

    3D structure databases

    ProteinModelPortali B2USY3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 512562.HPSH_02575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD47965 ; ACD47965 ; HPSH_02575 .
    GeneIDi 6296306.
    KEGGi hps:HPSH_02575.
    PATRICi 20612379. VBIHelPyl23559_0502.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi NACTQLA.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci HPYL512562:GHHZ-516-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
      Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Shi470.

    Entry informationi

    Entry nameiTHIM_HELPS
    AccessioniPrimary (citable) accession number: B2USY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3