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B2USI4 (B2USI4_HELPS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315
Ordered Locus Names:HPSH_01830
OrganismHelicobacter pylori (strain Shi470) [Complete proteome] [HAMAP]
Taxonomic identifier512562 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS001017

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS001017

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS001017

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS001017

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS001017

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
B2USI4 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: FC0716F069144938

FASTA61667,505
        10         20         30         40         50         60 
MQNKTFDLNP NDIAGLELVC QTLRSRILEV VSANGGHLSS SLGAVELIVS MHALFDCQKN 

        70         80         90        100        110        120 
PFIFDTSHQA YAHKLLTGRF ESFSTLRQFK GLSGFTKPSE SAYDYFIAGH SSTSVSIGVG 

       130        140        150        160        170        180 
VAKAFCLKQA LGMPIALLGD GSISAGIFYE ALNELGDRKY PMIMILNDNE MSISTPIGAL 

       190        200        210        220        230        240 
SKALSQLMKG PFYQSFRSKV KKILNTLPES VNYLASRFEE SFKLITPGVF FEELGINYIG 

       250        260        270        280        290        300 
PINGHDLSAI IETLKLAKEL KEPVLIHAQT LKGKGYKIAE GRYEKWHGVG PFDLDTGLSK 

       310        320        330        340        350        360 
KSKSAILSPT EAYSNTLLEL AKKDEKIVGV TAAMPSGTGL DKLIDAYPLR FFDVAIAEQH 

       370        380        390        400        410        420 
ALTSSSAMAK EGFKPFVSIY STFLQRAYDS IVHDACISSL PIKLAIDRAG IVGEDGETHQ 

       430        440        450        460        470        480 
GLLDVSYLRS IPNMVIFAPR DNETLKNAVR FANEHHSSPC AFRYPRGSFA LKEGVFEPSG 

       490        500        510        520        530        540 
FVLGQSELLK KEGEILLIGY GNGVGRAHLV QLALKEKNIE CALLDLRFLK PLDQNLSAII 

       550        560        570        580        590        600 
APYQKLYVFS DNYKLGGVAS AILEFLSEQN ILKPVKSFEI IDEFIMHGNT ALVEKSLGLD 

       610 
TESLTDAILK DLGQER

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References

[1]"Genome sequence of Helicobacter pylori from the remote Amazon: traces of Asian ancestry of the first Americans."
Kersulyte D., Kalia A., Gilman R.H., Berg D.E.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001072 Genomic DNA. Translation: ACD47816.1.
RefSeqYP_001909846.1. NC_010698.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2USI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6296159.
GenomeReviewsGene locus HPSH_01830 in contig CP001072_GR.
KEGGhps:HPSH_01830.
PATRIC20612075. VBIHelPyl23559_0352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG571647.
OMARAHEFES.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR004045. Glutathione_S-Trfase_N.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS50404. GST_NTER. 1 hit.
PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2USI4_HELPS
AccessionPrimary (citable) accession number: B2USI4
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info