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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

Amuc_0744

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-7-phosphoheptulonate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-767-MONOMER.
UniPathwayiUPA00053; UER00084.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthaseUniRule annotation
DAHP synthaseUniRule annotation
Phospho-2-keto-3-deoxyheptonate aldolaseUniRule annotation
Gene namesi
Ordered Locus Names:Amuc_0744Imported
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349741.Amuc_0744.

Structurei

3D structure databases

ProteinModelPortaliB2UQ45.
SMRiB2UQ45. Positions 8-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0722.
HOGENOMiHOG000220501.
KOiK01626.
OMAiDGCIDWA.
OrthoDBiEOG63JR9W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UQ45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNWFKTDDIR IQDIEPLISP AILIKDYPAT TEIAKMVATT RKNAENIISG
60 70 80 90 100
HDDRLLVVVG PCSIHDPQAA VDYASRLKEQ MARFEKDLVI IMRVYFEKPR
110 120 130 140 150
TTVGWKGLIN DPFMNHTFDI NRGLHMARGL LLRLGDMGVP AATEFLDTIT
160 170 180 190 200
PQYIADLITW GAIGARTTES QVHRELASGL SMPVGFKNGT SGSLQIAVDA
210 220 230 240 250
IVSSSCPHCF LSVTKQGVSA IVSTTGNKSC HLILRGSSLG PNFDEDHVKE
260 270 280 290 300
AEEALQKAGI NNRIMIDCSH GNSCKDYRKQ PAVAANIAEQ ISSGSEQVVA
310 320 330 340 350
VMIESNIVEG AQPLSSDLVY GKSITDQCIG WETTVEVLET LAAAVRKRRA

KRQEA
Length:355
Mass (Da):38,806
Last modified:July 1, 2008 - v1
Checksum:i7E3738688163E90E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04580.1.
RefSeqiYP_001877361.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD04580; ACD04580; Amuc_0744.
GeneIDi6275534.
KEGGiamu:Amuc_0744.
PATRICi20834180. VBIAkkMuc16855_0843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04580.1.
RefSeqiYP_001877361.1. NC_010655.1.

3D structure databases

ProteinModelPortaliB2UQ45.
SMRiB2UQ45. Positions 8-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349741.Amuc_0744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD04580; ACD04580; Amuc_0744.
GeneIDi6275534.
KEGGiamu:Amuc_0744.
PATRICi20834180. VBIAkkMuc16855_0843.

Phylogenomic databases

eggNOGiCOG0722.
HOGENOMiHOG000220501.
KOiK01626.
OMAiDGCIDWA.
OrthoDBiEOG63JR9W.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00084.
BioCyciAMUC349741:GHZ7-767-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835Imported.

Entry informationi

Entry nameiB2UQ45_AKKM8
AccessioniPrimary (citable) accession number: B2UQ45
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.