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B2UQ45

- B2UQ45_AKKM8

UniProt

B2UQ45 - B2UQ45_AKKM8

Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

Amuc_0744

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

    Catalytic activityi

    Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-deoxy-7-phosphoheptulonate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciAMUC349741:GHZ7-767-MONOMER.
    UniPathwayiUPA00053; UER00084.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
    Alternative name(s):
    3-deoxy-D-arabino-heptulosonate 7-phosphate synthaseUniRule annotation
    DAHP synthaseUniRule annotation
    Phospho-2-keto-3-deoxyheptonate aldolaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Amuc_0744Imported
    OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
    Taxonomic identifieri349741 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
    ProteomesiUP000001031: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi349741.Amuc_0744.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UQ45.
    SMRiB2UQ45. Positions 8-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I DAHP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0722.
    HOGENOMiHOG000220501.
    KOiK01626.
    OMAiDGCIDWA.
    OrthoDBiEOG63JR9W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006218. DAHP1/KDSA.
    IPR006219. DHAP_synth_1.
    [Graphical view]
    PANTHERiPTHR21225. PTHR21225. 1 hit.
    PfamiPF00793. DAHP_synth_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
    TIGRFAMsiTIGR00034. aroFGH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UQ45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNWFKTDDIR IQDIEPLISP AILIKDYPAT TEIAKMVATT RKNAENIISG    50
    HDDRLLVVVG PCSIHDPQAA VDYASRLKEQ MARFEKDLVI IMRVYFEKPR 100
    TTVGWKGLIN DPFMNHTFDI NRGLHMARGL LLRLGDMGVP AATEFLDTIT 150
    PQYIADLITW GAIGARTTES QVHRELASGL SMPVGFKNGT SGSLQIAVDA 200
    IVSSSCPHCF LSVTKQGVSA IVSTTGNKSC HLILRGSSLG PNFDEDHVKE 250
    AEEALQKAGI NNRIMIDCSH GNSCKDYRKQ PAVAANIAEQ ISSGSEQVVA 300
    VMIESNIVEG AQPLSSDLVY GKSITDQCIG WETTVEVLET LAAAVRKRRA 350
    KRQEA 355
    Length:355
    Mass (Da):38,806
    Last modified:July 1, 2008 - v1
    Checksum:i7E3738688163E90E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04580.1.
    RefSeqiYP_001877361.1. NC_010655.1.

    Genome annotation databases

    EnsemblBacteriaiACD04580; ACD04580; Amuc_0744.
    GeneIDi6275534.
    KEGGiamu:Amuc_0744.
    PATRICi20834180. VBIAkkMuc16855_0843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04580.1 .
    RefSeqi YP_001877361.1. NC_010655.1.

    3D structure databases

    ProteinModelPortali B2UQ45.
    SMRi B2UQ45. Positions 8-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349741.Amuc_0744.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD04580 ; ACD04580 ; Amuc_0744 .
    GeneIDi 6275534.
    KEGGi amu:Amuc_0744.
    PATRICi 20834180. VBIAkkMuc16855_0843.

    Phylogenomic databases

    eggNOGi COG0722.
    HOGENOMi HOG000220501.
    KOi K01626.
    OMAi DGCIDWA.
    OrthoDBi EOG63JR9W.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00084 .
    BioCyci AMUC349741:GHZ7-767-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006218. DAHP1/KDSA.
    IPR006219. DHAP_synth_1.
    [Graphical view ]
    PANTHERi PTHR21225. PTHR21225. 1 hit.
    Pfami PF00793. DAHP_synth_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001361. DAHP_synthase. 1 hit.
    TIGRFAMsi TIGR00034. aroFGH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
      van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
      PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-835Imported.

    Entry informationi

    Entry nameiB2UQ45_AKKM8
    AccessioniPrimary (citable) accession number: B2UQ45
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3