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B2UQ45

- B2UQ45_AKKM8

UniProt

B2UQ45 - B2UQ45_AKKM8

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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

Amuc_0744

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-7-phosphoheptulonate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-767-MONOMER.
UniPathwayiUPA00053; UER00084.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthaseUniRule annotation
DAHP synthaseUniRule annotation
Phospho-2-keto-3-deoxyheptonate aldolaseUniRule annotation
Gene namesi
Ordered Locus Names:Amuc_0744Imported
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349741.Amuc_0744.

Structurei

3D structure databases

ProteinModelPortaliB2UQ45.
SMRiB2UQ45. Positions 8-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0722.
HOGENOMiHOG000220501.
KOiK01626.
OMAiDGCIDWA.
OrthoDBiEOG63JR9W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
PANTHERiPTHR21225. PTHR21225. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsiTIGR00034. aroFGH. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UQ45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNWFKTDDIR IQDIEPLISP AILIKDYPAT TEIAKMVATT RKNAENIISG
60 70 80 90 100
HDDRLLVVVG PCSIHDPQAA VDYASRLKEQ MARFEKDLVI IMRVYFEKPR
110 120 130 140 150
TTVGWKGLIN DPFMNHTFDI NRGLHMARGL LLRLGDMGVP AATEFLDTIT
160 170 180 190 200
PQYIADLITW GAIGARTTES QVHRELASGL SMPVGFKNGT SGSLQIAVDA
210 220 230 240 250
IVSSSCPHCF LSVTKQGVSA IVSTTGNKSC HLILRGSSLG PNFDEDHVKE
260 270 280 290 300
AEEALQKAGI NNRIMIDCSH GNSCKDYRKQ PAVAANIAEQ ISSGSEQVVA
310 320 330 340 350
VMIESNIVEG AQPLSSDLVY GKSITDQCIG WETTVEVLET LAAAVRKRRA

KRQEA
Length:355
Mass (Da):38,806
Last modified:July 1, 2008 - v1
Checksum:i7E3738688163E90E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04580.1.
RefSeqiWP_012419795.1. NC_010655.1.
YP_001877361.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD04580; ACD04580; Amuc_0744.
GeneIDi6275534.
KEGGiamu:Amuc_0744.
PATRICi20834180. VBIAkkMuc16855_0843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04580.1 .
RefSeqi WP_012419795.1. NC_010655.1.
YP_001877361.1. NC_010655.1.

3D structure databases

ProteinModelPortali B2UQ45.
SMRi B2UQ45. Positions 8-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_0744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD04580 ; ACD04580 ; Amuc_0744 .
GeneIDi 6275534.
KEGGi amu:Amuc_0744.
PATRICi 20834180. VBIAkkMuc16855_0843.

Phylogenomic databases

eggNOGi COG0722.
HOGENOMi HOG000220501.
KOi K01626.
OMAi DGCIDWA.
OrthoDBi EOG63JR9W.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00084 .
BioCyci AMUC349741:GHZ7-767-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view ]
PANTHERi PTHR21225. PTHR21225. 1 hit.
Pfami PF00793. DAHP_synth_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsi TIGR00034. aroFGH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835Imported.

Entry informationi

Entry nameiB2UQ45_AKKM8
AccessioniPrimary (citable) accession number: B2UQ45
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3