B2UQ45 (B2UQ45_AKKM8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Ordered Locus Names:

Amuc_0744

Organism

Akkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP] EMBL ACD04580.1

Taxonomic identifier

349741 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Verrucomicrobia › Verrucomicrobiae › Verrucomicrobiales › Verrucomicrobiaceae › Akkermansia › Akkermansia muciniphila

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361 EMBL ACD04580.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2UQ45 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 7E3738688163E90E	FASTA	355	38,806
	10 20 30 40 50 60 MNWFKTDDIR IQDIEPLISP AILIKDYPAT TEIAKMVATT RKNAENIISG HDDRLLVVVG 70 80 90 100 110 120 PCSIHDPQAA VDYASRLKEQ MARFEKDLVI IMRVYFEKPR TTVGWKGLIN DPFMNHTFDI 130 140 150 160 170 180 NRGLHMARGL LLRLGDMGVP AATEFLDTIT PQYIADLITW GAIGARTTES QVHRELASGL 190 200 210 220 230 240 SMPVGFKNGT SGSLQIAVDA IVSSSCPHCF LSVTKQGVSA IVSTTGNKSC HLILRGSSLG 250 260 270 280 290 300 PNFDEDHVKE AEEALQKAGI NNRIMIDCSH GNSCKDYRKQ PAVAANIAEQ ISSGSEQVVA 310 320 330 340 350 VMIESNIVEG AQPLSSDLVY GKSITDQCIG WETTVEVLET LAAAVRKRRA KRQEA

References

[1]

"Complete sequence of Akkermansia muciniphila ATCC BAA-835." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-835 EMBL ACD04580.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001071 Genomic DNA. Translation: ACD04580.1.
RefSeq	YP_001877361.1. NC_010655.1.
3D structure databases
ProteinModelPortal	B2UQ45.
SMR	B2UQ45. Positions 8-349.
ModBase	Search...
Protein-protein interaction databases
STRING	349741.Amuc_0744.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD04580; ACD04580; Amuc_0744.
GeneID	6275534.
KEGG	amu:Amuc_0744.
PATRIC	20834180. VBIAkkMuc16855_0843.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0722.
HOGENOM	HOG000220501.
KO	K01626.
OMA	DINAMEL.
ProtClustDB	PRK09261.
Enzyme and pathway databases
BioCyc	AMUC349741:GHZ7-767-MONOMER.
UniPathway	UPA00053; UER00084.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
PANTHER	PTHR21225. PTHR21225. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. aroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2UQ45_AKKM8

Accession

Primary (citable) accession number: B2UQ45

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)