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B2UPI5

- B2UPI5_AKKM8

UniProt

B2UPI5 - B2UPI5_AKKM8

Protein
Submitted name:

Exo-alpha-sialidase

Gene

Amuc_0625

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    GlycosidaseImported, Hydrolase

    Enzyme and pathway databases

    BioCyciAMUC349741:GHZ7-647-MONOMER.

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
    Gene namesi
    Ordered Locus Names:Amuc_0625Imported
    OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
    Taxonomic identifieri349741 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
    ProteomesiUP000001031: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939 PotentialImportedAdd
    BLAST
    Chaini40 – 419380 PotentialImportedPRO_5000370509Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349741.Amuc_0625.

    Family & Domainsi

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG4409.
    KOiK01186.
    OMAiWRSYANT.
    OrthoDBiEOG61CM2G.

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B2UPI5-1 [UniParc]FASTAAdd to Basket

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    MTWLLCGRGK WNKVKRMMNS VFKCLMSAVC AVALPAFGQE EKTGFPTDRA    50
    VTVFSAGEGN PYASIRIPAL LSIGKGQLLA FAEGRYKNTD QGENDIIMSV 100
    SKNGGKTWSR PRAIAKAHGA TFNNPCPVYD AKTRTVTVVF QRYPAGVKER 150
    QPNIPDGWDD EKCIRNFMIQ SRNGGSSWTK PQEITKTTKR PSGVDIMASG 200
    PNAGTQLKSG AHKGRLVIPM NEGPFGKWVI SCIYSDDGGK SWKLGQPTAN 250
    MKGMVNETSI AETDNGGVVM VARHWGAGNC RRIAWSQDGG ETWGQVEDAP 300
    ELFCDSTQNS LMTYSLSDQP AYGGKSRILF SGPSAGRRIK GQVAMSYDNG 350
    KTWPVKKLLG EGGFAYSSLA MVEPGIVGVL YEENQEHIKK LKFVPITMEW 400
    LTDGEDTGLA PGKKAPVLK 419
    Length:419
    Mass (Da):45,589
    Last modified:July 1, 2008 - v1
    Checksum:i6CF910299C76EABA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04462.1.
    RefSeqiWP_012419677.1. NC_010655.1.
    YP_001877243.1. NC_010655.1.

    Genome annotation databases

    EnsemblBacteriaiACD04462; ACD04462; Amuc_0625.
    GeneIDi6274199.
    KEGGiamu:Amuc_0625.
    PATRICi20833906. VBIAkkMuc16855_0707.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04462.1 .
    RefSeqi WP_012419677.1. NC_010655.1.
    YP_001877243.1. NC_010655.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349741.Amuc_0625.

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD04462 ; ACD04462 ; Amuc_0625 .
    GeneIDi 6274199.
    KEGGi amu:Amuc_0625.
    PATRICi 20833906. VBIAkkMuc16855_0707.

    Phylogenomic databases

    eggNOGi COG4409.
    KOi K01186.
    OMAi WRSYANT.
    OrthoDBi EOG61CM2G.

    Enzyme and pathway databases

    BioCyci AMUC349741:GHZ7-647-MONOMER.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
      van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
      PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-835Imported.

    Entry informationi

    Entry nameiB2UPI5_AKKM8
    AccessioniPrimary (citable) accession number: B2UPI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3