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B2UPI5

- B2UPI5_AKKM8

UniProt

B2UPI5 - B2UPI5_AKKM8

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Protein
Submitted name:

Exo-alpha-sialidase

Gene

Amuc_0625

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-647-MONOMER.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
Ordered Locus Names:Amuc_0625Imported
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 PotentialImportedAdd
BLAST
Chaini40 – 419380 PotentialImportedPRO_5000370509Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349741.Amuc_0625.

Family & Domainsi

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG4409.
KOiK01186.
OMAiWRSYANT.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2UPI5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTWLLCGRGK WNKVKRMMNS VFKCLMSAVC AVALPAFGQE EKTGFPTDRA
60 70 80 90 100
VTVFSAGEGN PYASIRIPAL LSIGKGQLLA FAEGRYKNTD QGENDIIMSV
110 120 130 140 150
SKNGGKTWSR PRAIAKAHGA TFNNPCPVYD AKTRTVTVVF QRYPAGVKER
160 170 180 190 200
QPNIPDGWDD EKCIRNFMIQ SRNGGSSWTK PQEITKTTKR PSGVDIMASG
210 220 230 240 250
PNAGTQLKSG AHKGRLVIPM NEGPFGKWVI SCIYSDDGGK SWKLGQPTAN
260 270 280 290 300
MKGMVNETSI AETDNGGVVM VARHWGAGNC RRIAWSQDGG ETWGQVEDAP
310 320 330 340 350
ELFCDSTQNS LMTYSLSDQP AYGGKSRILF SGPSAGRRIK GQVAMSYDNG
360 370 380 390 400
KTWPVKKLLG EGGFAYSSLA MVEPGIVGVL YEENQEHIKK LKFVPITMEW
410
LTDGEDTGLA PGKKAPVLK
Length:419
Mass (Da):45,589
Last modified:July 1, 2008 - v1
Checksum:i6CF910299C76EABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04462.1.
RefSeqiYP_001877243.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD04462; ACD04462; Amuc_0625.
GeneIDi6274199.
KEGGiamu:Amuc_0625.
PATRICi20833906. VBIAkkMuc16855_0707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04462.1 .
RefSeqi YP_001877243.1. NC_010655.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_0625.

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD04462 ; ACD04462 ; Amuc_0625 .
GeneIDi 6274199.
KEGGi amu:Amuc_0625.
PATRICi 20833906. VBIAkkMuc16855_0707.

Phylogenomic databases

eggNOGi COG4409.
KOi K01186.
OMAi WRSYANT.
OrthoDBi EOG61CM2G.

Enzyme and pathway databases

BioCyci AMUC349741:GHZ7-647-MONOMER.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835Imported.

Entry informationi

Entry nameiB2UPI5_AKKM8
AccessioniPrimary (citable) accession number: B2UPI5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3