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B2UP55 (THIM_AKKM8) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Amuc_2016
OrganismAkkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP]
Taxonomic identifier349741 [NCBI]
Taxonomic lineageBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383818

Sites

Binding site501Substrate; via amide nitrogen By similarity
Binding site1261ATP By similarity
Binding site1721ATP By similarity
Binding site1991Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B2UP55 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 0E44B080AC223C6D

FASTA27127,898
        10         20         30         40         50         60 
MLSSTDLVQA VTADLGKIRE TAPLVLSLTN SVVQPLTANL LLAIGAVPAM LNDAEEAVDM 

        70         80         90        100        110        120 
LRSGTGALLV NLGTVTREQG AAMQTAVREA NRLNIPWVLD PVAVGALSLR TRLAGQLKEQ 

       130        140        150        160        170        180 
SPRIIRGNAS EIMALAGYSS VTKGPESTSS SADALHAARE LALHTGAAVL VTGRTDYSTD 

       190        200        210        220        230        240 
GRQVTATENG HAMMSRVTGV GCSMGALSAA CAAVSPTPLQ AAVSTAVLMG IAGEMAFEQS 

       250        260        270 
PSPGSFAVSL LDSLYALSPE DVVRRARFLS L 

« Hide

References

[1]"Complete sequence of Akkermansia muciniphila ATCC BAA-835."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. expand/collapse author list , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-835.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001071 Genomic DNA. Translation: ACD05826.1.
RefSeqYP_001878607.1. NC_010655.1.

3D structure databases

ProteinModelPortalB2UP55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349741.Amuc_2016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD05826; ACD05826; Amuc_2016.
GeneID6275623.
KEGGamu:Amuc_2016.
PATRIC20837156. VBIAkkMuc16855_2299.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycAMUC349741:GHZ7-2073-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_AKKM8
AccessionPrimary (citable) accession number: B2UP55
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways