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B2UNS0

- LFTR_AKKM8

UniProt

B2UNS0 - LFTR_AKKM8

Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

    Catalytic activityi

    L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
    L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

    GO - Molecular functioni

    1. leucyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciAMUC349741:GHZ7-2030-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
    Alternative name(s):
    L/F-transferaseUniRule annotation
    LeucyltransferaseUniRule annotation
    PhenyalanyltransferaseUniRule annotation
    Gene namesi
    Name:aatUniRule annotation
    Ordered Locus Names:Amuc_1973
    OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
    Taxonomic identifieri349741 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
    ProteomesiUP000001031: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Leucyl/phenylalanyl-tRNA--protein transferasePRO_1000131901Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349741.Amuc_1973.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UNS0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L/F-transferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2360.
    HOGENOMiHOG000102326.
    KOiK00684.
    OMAiWSPDPRG.
    OrthoDBiEOG6WX4R3.

    Family and domain databases

    HAMAPiMF_00688. Leu_Phe_trans.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR004616. Leu/Phe-tRNA_Trfase.
    [Graphical view]
    PfamiPF03588. Leu_Phe_trans. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR00667. aat. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UNS0-1 [UniParc]FASTAAdd to Basket

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    MNDRLTPELV LSAYCQGCFP MADPETGEIS FYEPDPRALI PLDDRFHIPH    50
    GLKRALNKKP FELRMDTAFP EVVHACARTD QPEEQWIDGQ IEEAYGKLHE 100
    MGFAHSVECW DEEGLQGGLY GVALGKAFFG ESMFHRKTDA SKIALVALVQ 150
    YLRAHRFLFL DTQWTTPHLL KFGTYEVPAK EYRKLLKRAL EEQ 193
    Length:193
    Mass (Da):22,173
    Last modified:July 1, 2008 - v1
    Checksum:i74646D56BA82817A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD05786.1.
    RefSeqiYP_001878567.1. NC_010655.1.

    Genome annotation databases

    EnsemblBacteriaiACD05786; ACD05786; Amuc_1973.
    GeneIDi6274891.
    KEGGiamu:Amuc_1973.
    PATRICi20837064. VBIAkkMuc16855_2253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD05786.1 .
    RefSeqi YP_001878567.1. NC_010655.1.

    3D structure databases

    ProteinModelPortali B2UNS0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349741.Amuc_1973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD05786 ; ACD05786 ; Amuc_1973 .
    GeneIDi 6274891.
    KEGGi amu:Amuc_1973.
    PATRICi 20837064. VBIAkkMuc16855_2253.

    Phylogenomic databases

    eggNOGi COG2360.
    HOGENOMi HOG000102326.
    KOi K00684.
    OMAi WSPDPRG.
    OrthoDBi EOG6WX4R3.

    Enzyme and pathway databases

    BioCyci AMUC349741:GHZ7-2030-MONOMER.

    Family and domain databases

    HAMAPi MF_00688. Leu_Phe_trans.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR004616. Leu/Phe-tRNA_Trfase.
    [Graphical view ]
    Pfami PF03588. Leu_Phe_trans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR00667. aat. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
      van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
      PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-835.

    Entry informationi

    Entry nameiLFTR_AKKM8
    AccessioniPrimary (citable) accession number: B2UNS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3