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B2UNJ5 (AROC_AKKM8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Amuc_1897
OrganismAkkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP]
Taxonomic identifier349741 [NCBI]
Taxonomic lineageBacteria › Verrucomicrobia › Verrucomicrobiae › Verrucomicrobiales › Verrucomicrobiaceae › Akkermansia

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Chorismate synthase HAMAP MF_00300
PRO_1000115324

Sequences

Sequence LengthMass (Da)Tools
B2UNJ5 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 281CE00138FFC9B5

FASTA36138,860
        10         20         30         40         50         60 
MSSSFGQVFR ISTWGESHGT GVGVVIDGCP SLVPVTEEDI QRELDRRRPG QSDIVTPRRE 

        70         80         90        100        110        120 
EDRAEILSGV LDGKTLGTPI AISVRNKDHR SSAYDEMART YRPSHADYTY DAKYGIRAWA 

       130        140        150        160        170        180 
GGGRASARET IGRVAAGAVA RAVLKQAFPD MEVVAWVDQV HHVKASVDWG AVTASAIESN 

       190        200        210        220        230        240 
IVRTADPSAA EAMIAAIKEA RDSGNSLGGV VKCVVRGCPP GLGDPVFDKL DATLAHAMMS 

       250        260        270        280        290        300 
IPATKAFAVG SGFEAADMTG LEHNDPFYMQ GCRVRTTTNH SGGIQGGISN GEDILMRIGF 

       310        320        330        340        350        360 
KPTATLMIDQ QTVNRDGEDA RLKGRGRHDA CVLPRAVPIV EAMAWLCLCD HYLRQRCQRA 


L

« Hide

References

[1]"Complete sequence of Akkermansia muciniphila ATCC BAA-835."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. expand/collapse author list , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-835.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001071 Genomic DNA. Translation: ACD05711.1.
RefSeqYP_001878492.1. NC_010655.1.

3D structure databases

ProteinModelPortalB2UNJ5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2UNJ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6273687.
GenomeReviewsGene locus Amuc_1897 in contig CP001071_GR.
KEGGamu:Amuc_1897.
PATRIC20836880. VBIAkkMuc16855_2163.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG292336.
OMAGVQGGIS.
ProtClustDBPRK05382.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_AKKM8
AccessionPrimary (citable) accession number: B2UNJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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