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B2UNH4

- GCSP_AKKM8

UniProt

B2UNH4 - GCSP_AKKM8

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAMUC349741:GHZ7-468-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Amuc_0448
    OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
    Taxonomic identifieri349741 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
    ProteomesiUP000001031: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 948948Glycine dehydrogenase (decarboxylating)PRO_1000190203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei696 – 6961N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi349741.Amuc_0448.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UNH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UNH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTHSDFASR HIGPQGEERR EMLDSLGYRT LDELIADIVP ADIRMKAPLD    50
    LPAAKSETEA LEELRSILRK NKLLKTFIGQ GYYGTITPSV ILRNVLENPG 100
    WYTAYTPYQP EIAQGRLEML MNFQTMVSSL TGLPVANASL LDEGTAAAEA 150
    VTMCRNARPK ANTFFVADTC HPQTISVIRT RAAFQGVNII VGDCSSFDPA 200
    SIGADLAGVL VQYPDTLGRI CDYTDFFSRV HATGALCVVA ADLMALTVIR 250
    EPGAFGADIC IGNTQHFGIP MGFGGPHAAY MSCTDALKRR MPGRLIGMSI 300
    DTLGRPAYRL ALQTREQHIR RDKATSNICT AQVLLAVLAA FYAVYHGQEG 350
    LKRIGTEIHL KTKSLYKALT EAGIAIENKN FFDTLLLSVP GQADAMVQKA 400
    LEAGYNIRRV DADHAAISLD ETATCADIAA LASALAGAET SAACDCDAPA 450
    WDPVHTRQTP FCTEKAFNSY HSETEMMRYI RRLESRDLAL NEAMIPLGSC 500
    TMKLNAASEM IPITWPEANS LHPFVPADQS EGIREMLSIL SDRLAKITGF 550
    AAVSLQPNAG AAGEYAGLLA IRRYQKHAGE GHRNVCLIPT SAHGTNPASS 600
    AMAGLKVVPV KCDERGNIDM ADLKSQAEAH KDNLSCIMVT YPSTHGVYEQ 650
    TIKELCDIVH ANGGQVYMDG ANMNAQVGLT CPGCIGADVC HLNLHKTFAM 700
    PHGGGGPGIG PIGVAEHLVP FLPGHLTLGH EEGAVASAAW GSASIAAICW 750
    MYLSMMGPDG LREATEMAIL NANYIAKKLG HLFPVLYSGN KGLVAHECIL 800
    DPRQLTHDAG LTVDDIAKRL MDYGFHGPTM SFPVPGTLMV EPTESEPKKE 850
    LDRFIEAMER IHAEITAIIN GTADKEDNVL KNSPHTAEMV SADEWRHPYS 900
    RSEAAYPVSG LLIHKFWPYV GRVDNVYGDR NLVCTCDTVE EFSKAVEL 948
    Length:948
    Mass (Da):102,650
    Last modified:July 1, 2008 - v1
    Checksum:iE26EDF5979A4EAF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04286.1.
    RefSeqiYP_001877067.1. NC_010655.1.

    Genome annotation databases

    EnsemblBacteriaiACD04286; ACD04286; Amuc_0448.
    GeneIDi6274573.
    KEGGiamu:Amuc_0448.
    PATRICi20833506. VBIAkkMuc16855_0509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04286.1 .
    RefSeqi YP_001877067.1. NC_010655.1.

    3D structure databases

    ProteinModelPortali B2UNH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349741.Amuc_0448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD04286 ; ACD04286 ; Amuc_0448 .
    GeneIDi 6274573.
    KEGGi amu:Amuc_0448.
    PATRICi 20833506. VBIAkkMuc16855_0509.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AMUC349741:GHZ7-468-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
      van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
      PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-835.

    Entry informationi

    Entry nameiGCSP_AKKM8
    AccessioniPrimary (citable) accession number: B2UNH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3