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B2UNH4 (GCSP_AKKM8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Amuc_0448
OrganismAkkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP]
Taxonomic identifier349741 [NCBI]
Taxonomic lineageBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia

Protein attributes

Sequence length948 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 948948Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000190203

Amino acid modifications

Modified residue6961N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2UNH4 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: E26EDF5979A4EAF0

FASTA948102,650
        10         20         30         40         50         60 
MNTHSDFASR HIGPQGEERR EMLDSLGYRT LDELIADIVP ADIRMKAPLD LPAAKSETEA 

        70         80         90        100        110        120 
LEELRSILRK NKLLKTFIGQ GYYGTITPSV ILRNVLENPG WYTAYTPYQP EIAQGRLEML 

       130        140        150        160        170        180 
MNFQTMVSSL TGLPVANASL LDEGTAAAEA VTMCRNARPK ANTFFVADTC HPQTISVIRT 

       190        200        210        220        230        240 
RAAFQGVNII VGDCSSFDPA SIGADLAGVL VQYPDTLGRI CDYTDFFSRV HATGALCVVA 

       250        260        270        280        290        300 
ADLMALTVIR EPGAFGADIC IGNTQHFGIP MGFGGPHAAY MSCTDALKRR MPGRLIGMSI 

       310        320        330        340        350        360 
DTLGRPAYRL ALQTREQHIR RDKATSNICT AQVLLAVLAA FYAVYHGQEG LKRIGTEIHL 

       370        380        390        400        410        420 
KTKSLYKALT EAGIAIENKN FFDTLLLSVP GQADAMVQKA LEAGYNIRRV DADHAAISLD 

       430        440        450        460        470        480 
ETATCADIAA LASALAGAET SAACDCDAPA WDPVHTRQTP FCTEKAFNSY HSETEMMRYI 

       490        500        510        520        530        540 
RRLESRDLAL NEAMIPLGSC TMKLNAASEM IPITWPEANS LHPFVPADQS EGIREMLSIL 

       550        560        570        580        590        600 
SDRLAKITGF AAVSLQPNAG AAGEYAGLLA IRRYQKHAGE GHRNVCLIPT SAHGTNPASS 

       610        620        630        640        650        660 
AMAGLKVVPV KCDERGNIDM ADLKSQAEAH KDNLSCIMVT YPSTHGVYEQ TIKELCDIVH 

       670        680        690        700        710        720 
ANGGQVYMDG ANMNAQVGLT CPGCIGADVC HLNLHKTFAM PHGGGGPGIG PIGVAEHLVP 

       730        740        750        760        770        780 
FLPGHLTLGH EEGAVASAAW GSASIAAICW MYLSMMGPDG LREATEMAIL NANYIAKKLG 

       790        800        810        820        830        840 
HLFPVLYSGN KGLVAHECIL DPRQLTHDAG LTVDDIAKRL MDYGFHGPTM SFPVPGTLMV 

       850        860        870        880        890        900 
EPTESEPKKE LDRFIEAMER IHAEITAIIN GTADKEDNVL KNSPHTAEMV SADEWRHPYS 

       910        920        930        940 
RSEAAYPVSG LLIHKFWPYV GRVDNVYGDR NLVCTCDTVE EFSKAVEL 

« Hide

References

[1]"Complete sequence of Akkermansia muciniphila ATCC BAA-835."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. expand/collapse author list , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-835.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001071 Genomic DNA. Translation: ACD04286.1.
RefSeqYP_001877067.1. NC_010655.1.

3D structure databases

ProteinModelPortalB2UNH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349741.Amuc_0448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD04286; ACD04286; Amuc_0448.
GeneID6274573.
KEGGamu:Amuc_0448.
PATRIC20833506. VBIAkkMuc16855_0509.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycAMUC349741:GHZ7-468-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_AKKM8
AccessionPrimary (citable) accession number: B2UNH4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families