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B2UNH4

- GCSP_AKKM8

UniProt

B2UNH4 - GCSP_AKKM8

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Amuc_0448
Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-468-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Amuc_0448
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000190203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei696 – 6961N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi349741.Amuc_0448.

Structurei

3D structure databases

ProteinModelPortaliB2UNH4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UNH4-1 [UniParc]FASTAAdd to Basket

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MNTHSDFASR HIGPQGEERR EMLDSLGYRT LDELIADIVP ADIRMKAPLD    50
LPAAKSETEA LEELRSILRK NKLLKTFIGQ GYYGTITPSV ILRNVLENPG 100
WYTAYTPYQP EIAQGRLEML MNFQTMVSSL TGLPVANASL LDEGTAAAEA 150
VTMCRNARPK ANTFFVADTC HPQTISVIRT RAAFQGVNII VGDCSSFDPA 200
SIGADLAGVL VQYPDTLGRI CDYTDFFSRV HATGALCVVA ADLMALTVIR 250
EPGAFGADIC IGNTQHFGIP MGFGGPHAAY MSCTDALKRR MPGRLIGMSI 300
DTLGRPAYRL ALQTREQHIR RDKATSNICT AQVLLAVLAA FYAVYHGQEG 350
LKRIGTEIHL KTKSLYKALT EAGIAIENKN FFDTLLLSVP GQADAMVQKA 400
LEAGYNIRRV DADHAAISLD ETATCADIAA LASALAGAET SAACDCDAPA 450
WDPVHTRQTP FCTEKAFNSY HSETEMMRYI RRLESRDLAL NEAMIPLGSC 500
TMKLNAASEM IPITWPEANS LHPFVPADQS EGIREMLSIL SDRLAKITGF 550
AAVSLQPNAG AAGEYAGLLA IRRYQKHAGE GHRNVCLIPT SAHGTNPASS 600
AMAGLKVVPV KCDERGNIDM ADLKSQAEAH KDNLSCIMVT YPSTHGVYEQ 650
TIKELCDIVH ANGGQVYMDG ANMNAQVGLT CPGCIGADVC HLNLHKTFAM 700
PHGGGGPGIG PIGVAEHLVP FLPGHLTLGH EEGAVASAAW GSASIAAICW 750
MYLSMMGPDG LREATEMAIL NANYIAKKLG HLFPVLYSGN KGLVAHECIL 800
DPRQLTHDAG LTVDDIAKRL MDYGFHGPTM SFPVPGTLMV EPTESEPKKE 850
LDRFIEAMER IHAEITAIIN GTADKEDNVL KNSPHTAEMV SADEWRHPYS 900
RSEAAYPVSG LLIHKFWPYV GRVDNVYGDR NLVCTCDTVE EFSKAVEL 948
Length:948
Mass (Da):102,650
Last modified:July 1, 2008 - v1
Checksum:iE26EDF5979A4EAF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001071 Genomic DNA. Translation: ACD04286.1.
RefSeqiYP_001877067.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD04286; ACD04286; Amuc_0448.
GeneIDi6274573.
KEGGiamu:Amuc_0448.
PATRICi20833506. VBIAkkMuc16855_0509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001071 Genomic DNA. Translation: ACD04286.1 .
RefSeqi YP_001877067.1. NC_010655.1.

3D structure databases

ProteinModelPortali B2UNH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_0448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD04286 ; ACD04286 ; Amuc_0448 .
GeneIDi 6274573.
KEGGi amu:Amuc_0448.
PATRICi 20833506. VBIAkkMuc16855_0509.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AMUC349741:GHZ7-468-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Akkermansia muciniphila ATCC BAA-835."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
    , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835.

Entry informationi

Entry nameiGCSP_AKKM8
AccessioniPrimary (citable) accession number: B2UNH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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