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B2UNH4

- GCSP_AKKM8

UniProt

B2UNH4 - GCSP_AKKM8

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-468-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Amuc_0448
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948Glycine dehydrogenase (decarboxylating)PRO_1000190203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei696 – 6961N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi349741.Amuc_0448.

Structurei

3D structure databases

ProteinModelPortaliB2UNH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UNH4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNTHSDFASR HIGPQGEERR EMLDSLGYRT LDELIADIVP ADIRMKAPLD
60 70 80 90 100
LPAAKSETEA LEELRSILRK NKLLKTFIGQ GYYGTITPSV ILRNVLENPG
110 120 130 140 150
WYTAYTPYQP EIAQGRLEML MNFQTMVSSL TGLPVANASL LDEGTAAAEA
160 170 180 190 200
VTMCRNARPK ANTFFVADTC HPQTISVIRT RAAFQGVNII VGDCSSFDPA
210 220 230 240 250
SIGADLAGVL VQYPDTLGRI CDYTDFFSRV HATGALCVVA ADLMALTVIR
260 270 280 290 300
EPGAFGADIC IGNTQHFGIP MGFGGPHAAY MSCTDALKRR MPGRLIGMSI
310 320 330 340 350
DTLGRPAYRL ALQTREQHIR RDKATSNICT AQVLLAVLAA FYAVYHGQEG
360 370 380 390 400
LKRIGTEIHL KTKSLYKALT EAGIAIENKN FFDTLLLSVP GQADAMVQKA
410 420 430 440 450
LEAGYNIRRV DADHAAISLD ETATCADIAA LASALAGAET SAACDCDAPA
460 470 480 490 500
WDPVHTRQTP FCTEKAFNSY HSETEMMRYI RRLESRDLAL NEAMIPLGSC
510 520 530 540 550
TMKLNAASEM IPITWPEANS LHPFVPADQS EGIREMLSIL SDRLAKITGF
560 570 580 590 600
AAVSLQPNAG AAGEYAGLLA IRRYQKHAGE GHRNVCLIPT SAHGTNPASS
610 620 630 640 650
AMAGLKVVPV KCDERGNIDM ADLKSQAEAH KDNLSCIMVT YPSTHGVYEQ
660 670 680 690 700
TIKELCDIVH ANGGQVYMDG ANMNAQVGLT CPGCIGADVC HLNLHKTFAM
710 720 730 740 750
PHGGGGPGIG PIGVAEHLVP FLPGHLTLGH EEGAVASAAW GSASIAAICW
760 770 780 790 800
MYLSMMGPDG LREATEMAIL NANYIAKKLG HLFPVLYSGN KGLVAHECIL
810 820 830 840 850
DPRQLTHDAG LTVDDIAKRL MDYGFHGPTM SFPVPGTLMV EPTESEPKKE
860 870 880 890 900
LDRFIEAMER IHAEITAIIN GTADKEDNVL KNSPHTAEMV SADEWRHPYS
910 920 930 940
RSEAAYPVSG LLIHKFWPYV GRVDNVYGDR NLVCTCDTVE EFSKAVEL
Length:948
Mass (Da):102,650
Last modified:July 1, 2008 - v1
Checksum:iE26EDF5979A4EAF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04286.1.
RefSeqiYP_001877067.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD04286; ACD04286; Amuc_0448.
GeneIDi6274573.
KEGGiamu:Amuc_0448.
PATRICi20833506. VBIAkkMuc16855_0509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD04286.1 .
RefSeqi YP_001877067.1. NC_010655.1.

3D structure databases

ProteinModelPortali B2UNH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_0448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD04286 ; ACD04286 ; Amuc_0448 .
GeneIDi 6274573.
KEGGi amu:Amuc_0448.
PATRICi 20833506. VBIAkkMuc16855_0509.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AMUC349741:GHZ7-468-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835.

Entry informationi

Entry nameiGCSP_AKKM8
AccessioniPrimary (citable) accession number: B2UNH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3