Reviewed, UniProtKB/Swiss-Prot B2UND0 (PANC_AKKM8)

Names and origin

Protein names

Recommended name:
    Pantothenate synthetase
      Short name=PS
    EC=6.3.2.1
Alternative name(s):
    Pantoate--beta-alanine ligase
    Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	Amuc_0404

Organism

Akkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP]

Taxonomic identifier

349741 [NCBI]

Taxonomic lineage

Bacteria › Verrucomicrobia › Verrucomicrobiae › Verrucomicrobiales › Verrucomicrobiaceae › Akkermansia

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Pantothenate synthetase HAMAP MF_00158		PRO_1000097026
Regions
	Nucleotide binding	30 – 37	8	ATP By similarity
	Nucleotide binding	150 – 153	4	ATP By similarity
	Nucleotide binding	187 – 190	4	ATP By similarity
Sites
	Active site	37	1	Proton donor By similarity
	Binding site	64	1	Beta-alanine By similarity
	Binding site	64	1	Pantoate By similarity
	Binding site	156	1	Pantoate By similarity
	Binding site	179	1	ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2UND0-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: CC39BF5AD725D307	FASTA	281	30,917
	10 20 30 40 50 60 MQTFSTKAQL RAALLKHHRK HDHVVLVPTM GALHAGHRAL LEQARKLAGE DGVVVASIFV 70 80 90 100 110 120 NPIQFNNSSD LQTYPRTPEK DLEVCEGAGV DYVFSPAPEE MYSGERSIAV EESFLSATLC 130 140 150 160 170 180 GASRPGHFSG VCTVLAKLFN LVQPTDAIFG KKDYQQLAII RRMVRDLDFP VRIHGAEIVR 190 200 210 220 230 240 HGNGLAYSSR NARLTPEQKE QAVVIRQAML QARDEFQAGA DASKVKEHAA AMIEGVPGTR 250 260 270 280 IDYLEIVDAE TMQPVAENRK PALMAAAVYF GDVRLIDNIE L

References

[1]

"Complete sequence of Akkermansia muciniphila ATCC BAA-835." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001071 Genomic DNA. Translation: ACD04242.1.
RefSeq	YP_001877023.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6274820.
GenomeReviews	Gene locus Amuc_0404 in contig CP001071_GR.
KEGG	amu:Amuc_0404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SRNVYLN.
Family and domain databases
HAMAP	MF_00158. [Tree]
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_AKKM8

Accession

Primary (citable) accession number: B2UND0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)