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B2UN99

- B2UN99_AKKM8

UniProt

B2UN99 - B2UN99_AKKM8

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Protein

Glutamate decarboxylase

Gene

Amuc_0372

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:Amuc_0372Imported
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349741.Amuc_0372.

Structurei

3D structure databases

ProteinModelPortaliB2UN99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiMIGRLFN.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UN99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDPNQKPDT ARAENSIFGS PEADNLLPKD EFPDYAMRAE DAFQLVSDEL
60 70 80 90 100
MLDGNARQNL ATFCQTWDEK QVRMLMNLSI NKNMIDKDEY PQTAAIEMRC
110 120 130 140 150
AAIIANLWNA SQNEKPIGCS TIGSSEACML GGMAALWRWR ARRKAAGKPI
160 170 180 190 200
DKPNLVCGPV QICWHKFCRY WDIEMREIPM VPGKWKMDVD RMLEQIDENT
210 220 230 240 250
IVVVPTFGVT YTGAYELPAE IAKALDDYEN KTGISVDIHV DGASGGFLAP
260 270 280 290 300
FCAPDLVFDF RIPRVKSISA SGHKYGLAPL GVGWVVWRDI SELPEGLIFN
310 320 330 340 350
VNYLGGEIPN FAINFSRPAG QIICQYYDFI RLGKEGYTNI HTQAYEVAKY
360 370 380 390 400
ISDELSKLGP YEFICTGDPE KGIPAVCFFI KDGARANYTL FDLSDKLRTR
410 420 430 440 450
GWQVPAFTLP ANCQDTVVMR VMVRQGFSKD LADLFLEDYK RMLSFFEKHP
460
VSSPMTAEEG TAFHHS
Length:466
Mass (Da):52,458
Last modified:July 1, 2008 - v1
Checksum:i01AAA28F18791379
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001071 Genomic DNA. Translation: ACD04211.1.
RefSeqiWP_012419426.1. NC_010655.1.
YP_001876992.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD04211; ACD04211; Amuc_0372.
GeneIDi6274901.
KEGGiamu:Amuc_0372.
PATRICi20833338. VBIAkkMuc16855_0425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001071 Genomic DNA. Translation: ACD04211.1 .
RefSeqi WP_012419426.1. NC_010655.1.
YP_001876992.1. NC_010655.1.

3D structure databases

ProteinModelPortali B2UN99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_0372.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD04211 ; ACD04211 ; Amuc_0372 .
GeneIDi 6274901.
KEGGi amu:Amuc_0372.
PATRICi 20833338. VBIAkkMuc16855_0425.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
KOi K01580.
OMAi MIGRLFN.
OrthoDBi EOG6TFCPW.

Enzyme and pathway databases

BioCyci AMUC349741:GHZ7-392-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835Imported.

Entry informationi

Entry nameiB2UN99_AKKM8
AccessioniPrimary (citable) accession number: B2UN99
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3