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B2UN99

- B2UN99_AKKM8

UniProt

B2UN99 - B2UN99_AKKM8

Protein

Glutamate decarboxylase

Gene

Amuc_0372

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciAMUC349741:GHZ7-392-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Ordered Locus Names:Amuc_0372Imported
    OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
    Taxonomic identifieri349741 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
    ProteomesiUP000001031: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi349741.Amuc_0372.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UN99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiMIGRLFN.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UN99-1 [UniParc]FASTAAdd to Basket

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    MFDPNQKPDT ARAENSIFGS PEADNLLPKD EFPDYAMRAE DAFQLVSDEL    50
    MLDGNARQNL ATFCQTWDEK QVRMLMNLSI NKNMIDKDEY PQTAAIEMRC 100
    AAIIANLWNA SQNEKPIGCS TIGSSEACML GGMAALWRWR ARRKAAGKPI 150
    DKPNLVCGPV QICWHKFCRY WDIEMREIPM VPGKWKMDVD RMLEQIDENT 200
    IVVVPTFGVT YTGAYELPAE IAKALDDYEN KTGISVDIHV DGASGGFLAP 250
    FCAPDLVFDF RIPRVKSISA SGHKYGLAPL GVGWVVWRDI SELPEGLIFN 300
    VNYLGGEIPN FAINFSRPAG QIICQYYDFI RLGKEGYTNI HTQAYEVAKY 350
    ISDELSKLGP YEFICTGDPE KGIPAVCFFI KDGARANYTL FDLSDKLRTR 400
    GWQVPAFTLP ANCQDTVVMR VMVRQGFSKD LADLFLEDYK RMLSFFEKHP 450
    VSSPMTAEEG TAFHHS 466
    Length:466
    Mass (Da):52,458
    Last modified:July 1, 2008 - v1
    Checksum:i01AAA28F18791379
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04211.1.
    RefSeqiYP_001876992.1. NC_010655.1.

    Genome annotation databases

    EnsemblBacteriaiACD04211; ACD04211; Amuc_0372.
    GeneIDi6274901.
    KEGGiamu:Amuc_0372.
    PATRICi20833338. VBIAkkMuc16855_0425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD04211.1 .
    RefSeqi YP_001876992.1. NC_010655.1.

    3D structure databases

    ProteinModelPortali B2UN99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349741.Amuc_0372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD04211 ; ACD04211 ; Amuc_0372 .
    GeneIDi 6274901.
    KEGGi amu:Amuc_0372.
    PATRICi 20833338. VBIAkkMuc16855_0425.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi MIGRLFN.
    OrthoDBi EOG6TFCPW.

    Enzyme and pathway databases

    BioCyci AMUC349741:GHZ7-392-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
      van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
      PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-835Imported.

    Entry informationi

    Entry nameiB2UN99_AKKM8
    AccessioniPrimary (citable) accession number: B2UN99
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3