Reviewed, UniProtKB/Swiss-Prot B2UN97 (AROA_AKKM8)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Amuc_1894

Organism

Akkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP]

Taxonomic identifier

349741 [NCBI]

Taxonomic lineage

Bacteria › Verrucomicrobia › Verrucomicrobiae › Verrucomicrobiales › Verrucomicrobiaceae › Akkermansia

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099661

Sequences

	Sequence		Length	Mass (Da)
	B2UN97-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 2AAF51C17D048294	FASTA	435	46,106
	10 20 30 40 50 60 MNLHSHSISS LQGALTVPGD KSISHRAAIL GGLAEGVTEV DNFLCSEDCL NTLRAMEQLG 70 80 90 100 110 120 AKVDVLEERQ GYGPVRFRIT GVAMSPKAPE RPIDCGNSGT GMRLLAGMLA ACPFDSEMFG 130 140 150 160 170 180 DASLSSRPMG RIMQPLEQMG ARIEARGAKP GCAPLSIHGG RVHPISYTLP MASAQVKSAI 190 200 210 220 230 240 LLAGMFADGT TTVRQPAVTR DHTERLFRHF GVPCTVDGLT VGTCGPALPV AHDLTVPADI 250 260 270 280 290 300 SSAAFWMVAA ASRPGSRLTL RQVGLNKTRN AVISALQRMG ARMDIVPTSP EDAGEPYGDI 310 320 330 340 350 360 TVYGSDSLHG TSLLPEEIPN LIDEIPILAV AGALGRGDFI VRNARELRVK ETDRIATTAA 370 380 390 400 410 420 NLRLMGVDVE EFDDGMVVHG GTPLKGTELS SYGDHRIAMS FLVAGLSAQG ETVVTDAECI 430 NTSYPGFERD LAQFL

References

[1]

"Complete sequence of Akkermansia muciniphila ATCC BAA-835." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001071 Genomic DNA. Translation: ACD05708.1.
RefSeq	YP_001878489.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6273816.
GenomeReviews	Gene locus Amuc_1894 in contig CP001071_GR.
KEGG	amu:Amuc_1894.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TENGMEL.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_AKKM8

Accession

Primary (citable) accession number: B2UN97

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)