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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Akkermansia muciniphila (strain ATCC BAA-835 / Muc)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei214ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMUC349741:G1GBX-2013-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Amuc_1888
OrganismiAkkermansia muciniphila (strain ATCC BAA-835 / Muc)
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesAkkermansiaceaeAkkermansia
Proteomesi
  • UP000001031 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003676041 – 433Glutamate--tRNA ligaseAdd BLAST433

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349741.Amuc_1888

Structurei

3D structure databases

ProteinModelPortaliB2UN91
SMRiB2UN91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi211 – 215"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 2 hits
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B2UN91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVRTRFAP SPTGYLHIGG ARTALFNWLF ARKMGGTFIL RIEDTDNARN
60 70 80 90 100
TEEATRAIFT GMEWLGLDWD EGPMKGGDCG PYFQSQRNDI YDAYFKKLQD
110 120 130 140 150
AGRVYEDEGA WRFRFDRSKP VTFHDLICGN ITIDYRDASN TPDMAIRRAD
160 170 180 190 200
GSYIFHFVNV VDDIEMKMTH VIRGEDHIMN TPKHIQLFEA FGVTPPVFAH
210 220 230 240 250
MPLILNQDGS KMSKRDVGAA LGTYPEEGFL PEGVMNFLAL LGWSPKDDTE
260 270 280 290 300
IFSPQELIGR FSLEAVNHSA AKFDITKCRW VNQQHIIALP AEEFALRARP
310 320 330 340 350
FCLKAGLPDS PILDAAIATV QTKVQTLAEV PDKIRFFFDL GMDPEAVSKV
360 370 380 390 400
QPEALELLFK LADRLEQEPE WDGHELIGVL KAFAKENGVK MGAVMFPARV
410 420 430
ALTGLSGGPD LSSVFSLLGR EETVRRIRSF SLD
Length:433
Mass (Da):48,607
Last modified:July 1, 2008 - v1
Checksum:i1C151550DCEB705F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA Translation: ACD05702.1
RefSeqiWP_012420916.1, NC_010655.1

Genome annotation databases

EnsemblBacteriaiACD05702; ACD05702; Amuc_1888
GeneIDi34174310
KEGGiamu:Amuc_1888

Similar proteinsi

Entry informationi

Entry nameiSYE_AKKM8
AccessioniPrimary (citable) accession number: B2UN91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health