B2UN63 (B2UN63_AKKM8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Amuc_1860

Organism

Akkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP] EMBL ACD05674.1

Taxonomic identifier

349741 [NCBI]

Taxonomic lineage

Bacteria › Verrucomicrobia › Verrucomicrobiae › Verrucomicrobiales › Verrucomicrobiaceae › Akkermansia

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543
Ligand	ATP-binding HAMAP MF_01543 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 EMBL ACD05674.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	70 – 77	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B2UN63 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 7016C54C68F0F4B4	FASTA	557	59,796
	10 20 30 40 50 60 MPMNLLAKRG GFRHHVRMVT PAFSDCINKL GVDEKDVIPF GRNKAKISLD VLDKPATPGK 70 80 90 100 110 120 LILVSAITPT PSGEGKTTVS IGLAQGLQAI GKKVCLALRQ PSMGPVFGRK GGATGGGKSS 130 140 150 160 170 180 LTPAEEINMH FTGDFHAITS AHNLISAIID NAMFFHTLNI DERKVIWKRV MDMNDRSLRS 190 200 210 220 230 240 IIVGLNKQGF PRETGFDITP ASEIMACLCL ATSYKDMEER INRIVIGFTT DDKPVFAREL 250 260 270 280 290 300 GITGSVMSLL KDALMPNLVQ SVEGVPCFLH GGPFANIAHG CNSVLATRMA LHFGDYAVTE 310 320 330 340 350 360 AGFAFDLGAE KFLDIKCRQS GLDPAAIVIV ATARALKMHG GTALADLKNT DVDALKKGLA 370 380 390 400 410 420 NLDAHLDAAA HYKRPVVVAV NKFFDDSREE LDAIVKHCAE RGIPCAIADI FSQGGEGGKD 430 440 450 460 470 480 LAQMVVEAAD RSSAPFKPLY ESALPVEEKL NIIARNIYGA DGVELTAAAK KKLAQFEASR 490 500 510 520 530 540 LTDLPICMAK TQNSLSDNGR LRGRPTGFTI TVRDFEIANG AGFLVALCGE IMRMPALPVS 550 PNAMHIYLDD KGNVQGL

References

[1]

"Complete sequence of Akkermansia muciniphila ATCC BAA-835." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC BAA-835 EMBL ACD05674.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001071 Genomic DNA. Translation: ACD05674.1.
RefSeq	YP_001878455.1. NC_010655.1.
3D structure databases
ProteinModelPortal	B2UN63.
SMR	B2UN63. Positions 23-556.
ModBase	Search...
Protein-protein interaction databases
STRING	B2UN63.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6275480.
GenomeReviews	Gene locus Amuc_1860 in contig CP001071_GR.
KEGG	amu:Amuc_1860.
PATRIC	20836788. VBIAkkMuc16855_2117.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	TDFTVTI.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2UN63_AKKM8

Accession

Primary (citable) accession number: B2UN63

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)