ID   B2UN42_AKKM8            Unreviewed;       674 AA.
AC   B2UN42;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Exo-alpha-sialidase {ECO:0000313|EMBL:ACD05653.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:ACD05653.1};
GN   OrderedLocusNames=Amuc_1835 {ECO:0000313|EMBL:ACD05653.1};
OS   Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS   81048 / CCUG 64013 / CIP 107961 / Muc).
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05653.1, ECO:0000313|Proteomes:UP000001031};
RN   [1] {ECO:0000313|Proteomes:UP000001031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC   / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
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DR   EMBL; CP001071; ACD05653.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2UN42; -.
DR   STRING; 349741.Amuc_1835; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 349741-Amuc_1835; -.
DR   KEGG; amu:Amuc_1835; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_0; -.
DR   Proteomes; UP000001031; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:ACD05653.1};
KW   Hydrolase {ECO:0000313|EMBL:ACD05653.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001031}.
FT   DOMAIN          168..304
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          336..614
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   674 AA;  72840 MW;  6ECC9CBD11BDF1A9 CRC64;
     MGLGLLCALG LSIPSVLGKE SFEQARRGKF TTLSTKYGLM SCRNGVAEIG GGGKSGEASL
     RMFGGQDAEL KLDLKDTPSR EVRLSAWAER WTGQAPFEFS IVAIGPNGEK KIYDGKDIRT
     GGFHTRIEAS VPAGTRSLVF RLTSPENKGM KLDDLFLVPC IPMKVNPQVE MASSAYPVMV
     RIPCSPVLSL NVRTDGCLNP QFLTAVNLDF TGTTKLSDIE SVAVIRGEEA PIIHHGEEPF
     PKDSSQVLGT VKLAGSARPQ ISVKGKMELE PGDNYLWACV TMKEGASLDG RVVVRPASVV
     AGNKPVRVAN AAPVAQRIGV AVVRHGDFKS KFYRIPGLAR SRKGTLLAVY DIRYNHSGDL
     PANIDVGVSR STDGGRTWSD VKIAIDDSKI DPSLGATRGV GDPAILVDEK TGRIWVAAIW
     SHRHSIWGSK SGDNSPEACG QLVLAYSDDD GLTWSSPINI TEQTKNKDWR ILFNGPGNGI
     CMKDGTLVFA AQYWDGKGVP WSTIVYSKDR GKTWHCGTGV NQQTTEAQVI ELEDGSVMIN
     ARCNWGGSRI VGVTKDLGQT WEKHPTNRTA QLKEPVCQGS LLAVDGVPGA GRVVLFSNPN
     TTSGRSHMTL KASTNDAGSW PEDKWLLYDA RKGWGYSCLA PVDKNHVGVL YESQGALNFL
     KIPYKDVLNA KNAR
//