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B2UN42

- B2UN42_AKKM8

UniProt

B2UN42 - B2UN42_AKKM8

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Protein
Submitted name:

Exo-alpha-sialidase

Gene

Amuc_1835

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-1890-MONOMER.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
Ordered Locus Names:Amuc_1835Imported
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)Imported
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 PotentialImportedAdd
BLAST
Chaini20 – 674655 PotentialImportedPRO_5000370394Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349741.Amuc_1835.

Family & Domainsi

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000252336.
KOiK01186.
OrthoDBiEOG67DPK3.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF14873. BNR_assoc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2UN42-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGLGLLCALG LSIPSVLGKE SFEQARRGKF TTLSTKYGLM SCRNGVAEIG
60 70 80 90 100
GGGKSGEASL RMFGGQDAEL KLDLKDTPSR EVRLSAWAER WTGQAPFEFS
110 120 130 140 150
IVAIGPNGEK KIYDGKDIRT GGFHTRIEAS VPAGTRSLVF RLTSPENKGM
160 170 180 190 200
KLDDLFLVPC IPMKVNPQVE MASSAYPVMV RIPCSPVLSL NVRTDGCLNP
210 220 230 240 250
QFLTAVNLDF TGTTKLSDIE SVAVIRGEEA PIIHHGEEPF PKDSSQVLGT
260 270 280 290 300
VKLAGSARPQ ISVKGKMELE PGDNYLWACV TMKEGASLDG RVVVRPASVV
310 320 330 340 350
AGNKPVRVAN AAPVAQRIGV AVVRHGDFKS KFYRIPGLAR SRKGTLLAVY
360 370 380 390 400
DIRYNHSGDL PANIDVGVSR STDGGRTWSD VKIAIDDSKI DPSLGATRGV
410 420 430 440 450
GDPAILVDEK TGRIWVAAIW SHRHSIWGSK SGDNSPEACG QLVLAYSDDD
460 470 480 490 500
GLTWSSPINI TEQTKNKDWR ILFNGPGNGI CMKDGTLVFA AQYWDGKGVP
510 520 530 540 550
WSTIVYSKDR GKTWHCGTGV NQQTTEAQVI ELEDGSVMIN ARCNWGGSRI
560 570 580 590 600
VGVTKDLGQT WEKHPTNRTA QLKEPVCQGS LLAVDGVPGA GRVVLFSNPN
610 620 630 640 650
TTSGRSHMTL KASTNDAGSW PEDKWLLYDA RKGWGYSCLA PVDKNHVGVL
660 670
YESQGALNFL KIPYKDVLNA KNAR
Length:674
Mass (Da):72,840
Last modified:July 1, 2008 - v1
Checksum:i6ECC9CBD11BDF1A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD05653.1.
RefSeqiWP_012420867.1. NC_010655.1.
YP_001878434.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD05653; ACD05653; Amuc_1835.
GeneIDi6275505.
KEGGiamu:Amuc_1835.
PATRICi20836722. VBIAkkMuc16855_2085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD05653.1 .
RefSeqi WP_012420867.1. NC_010655.1.
YP_001878434.1. NC_010655.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_1835.

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD05653 ; ACD05653 ; Amuc_1835 .
GeneIDi 6275505.
KEGGi amu:Amuc_1835.
PATRICi 20836722. VBIAkkMuc16855_2085.

Phylogenomic databases

eggNOGi COG4409.
HOGENOMi HOG000252336.
KOi K01186.
OrthoDBi EOG67DPK3.

Enzyme and pathway databases

BioCyci AMUC349741:GHZ7-1890-MONOMER.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF14873. BNR_assoc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835Imported.

Entry informationi

Entry nameiB2UN42_AKKM8
AccessioniPrimary (citable) accession number: B2UN42
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3