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B2UL96

- GLSA_AKKM8

UniProt

B2UL96 - GLSA_AKKM8

Protein

Glutaminase

Gene

glsA

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei171 – 1711SubstrateUniRule annotation
    Binding sitei195 – 1951SubstrateUniRule annotation
    Binding sitei247 – 2471SubstrateUniRule annotation
    Binding sitei265 – 2651Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciAMUC349741:GHZ7-40-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:Amuc_0038
    OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
    Taxonomic identifieri349741 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
    ProteomesiUP000001031: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313GlutaminasePRO_1000115690Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349741.Amuc_0038.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UL96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQCSVGVT.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UL96-1 [UniParc]FASTAAdd to Basket

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    MSDIPSNEQI RTALDNAYAY AKTVQGGKNA SYIPALAQVP SDLLAIAVVT    50
    VNGDLLTAGS ADAPFAIESI SKAFNLAYVM DLIGMKQLRA KIGADPTGEP 100
    FNSVMAIELH GGKPLNPLVN AGAMATVSLV NGSDSDEIWG NMIHNFNNFA 150
    NTALTVNQEI YKSESATNQH NRGIAWLLDS YGYFYNTPPM IVDLYTRMCS 200
    LNITASQLAL MGACYANGGV NPVSKKRVVK EENVPPILAE MCMSGLYDST 250
    GDWMYKAGLP AKSGVGGGLV AVAPGKLAMA AFSPPLDPAG NTVKGQAALQ 300
    SIIRELNLNL FRS 313
    Length:313
    Mass (Da):33,127
    Last modified:July 1, 2008 - v1
    Checksum:i1FA51CFF16A29FE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD03885.1.
    RefSeqiWP_012419100.1. NC_010655.1.
    YP_001876666.1. NC_010655.1.

    Genome annotation databases

    EnsemblBacteriaiACD03885; ACD03885; Amuc_0038.
    GeneIDi6275164.
    KEGGiamu:Amuc_0038.
    PATRICi20832542. VBIAkkMuc16855_0044.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001071 Genomic DNA. Translation: ACD03885.1 .
    RefSeqi WP_012419100.1. NC_010655.1.
    YP_001876666.1. NC_010655.1.

    3D structure databases

    ProteinModelPortali B2UL96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349741.Amuc_0038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD03885 ; ACD03885 ; Amuc_0038 .
    GeneIDi 6275164.
    KEGGi amu:Amuc_0038.
    PATRICi 20832542. VBIAkkMuc16855_0044.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QCSVGVT.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci AMUC349741:GHZ7-40-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
      van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
      PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-835.

    Entry informationi

    Entry nameiGLSA_AKKM8
    AccessioniPrimary (citable) accession number: B2UL96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3