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Protein

Glutaminase

Gene

glsA

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691SubstrateUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Binding sitei171 – 1711SubstrateUniRule annotation
Binding sitei195 – 1951SubstrateUniRule annotation
Binding sitei247 – 2471SubstrateUniRule annotation
Binding sitei265 – 2651Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-40-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:Amuc_0038
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313GlutaminasePRO_1000115690Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349741.Amuc_0038.

Structurei

3D structure databases

ProteinModelPortaliB2UL96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UL96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIPSNEQI RTALDNAYAY AKTVQGGKNA SYIPALAQVP SDLLAIAVVT
60 70 80 90 100
VNGDLLTAGS ADAPFAIESI SKAFNLAYVM DLIGMKQLRA KIGADPTGEP
110 120 130 140 150
FNSVMAIELH GGKPLNPLVN AGAMATVSLV NGSDSDEIWG NMIHNFNNFA
160 170 180 190 200
NTALTVNQEI YKSESATNQH NRGIAWLLDS YGYFYNTPPM IVDLYTRMCS
210 220 230 240 250
LNITASQLAL MGACYANGGV NPVSKKRVVK EENVPPILAE MCMSGLYDST
260 270 280 290 300
GDWMYKAGLP AKSGVGGGLV AVAPGKLAMA AFSPPLDPAG NTVKGQAALQ
310
SIIRELNLNL FRS
Length:313
Mass (Da):33,127
Last modified:July 1, 2008 - v1
Checksum:i1FA51CFF16A29FE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD03885.1.
RefSeqiYP_001876666.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD03885; ACD03885; Amuc_0038.
GeneIDi6275164.
KEGGiamu:Amuc_0038.
PATRICi20832542. VBIAkkMuc16855_0044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD03885.1.
RefSeqiYP_001876666.1. NC_010655.1.

3D structure databases

ProteinModelPortaliB2UL96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349741.Amuc_0038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD03885; ACD03885; Amuc_0038.
GeneIDi6275164.
KEGGiamu:Amuc_0038.
PATRICi20832542. VBIAkkMuc16855_0044.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-40-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835.

Entry informationi

Entry nameiGLSA_AKKM8
AccessioniPrimary (citable) accession number: B2UL96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: March 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.