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B2UL96 (GLSA_AKKM8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase

EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:Amuc_0038
OrganismAkkermansia muciniphila (strain ATCC BAA-835) [Complete proteome] [HAMAP]
Taxonomic identifier349741 [NCBI]
Taxonomic lineageBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Glutaminase HAMAP-Rule MF_00313
PRO_1000115690

Sites

Binding site691Substrate By similarity
Binding site1201Substrate By similarity
Binding site1641Substrate By similarity
Binding site1711Substrate By similarity
Binding site1951Substrate By similarity
Binding site2471Substrate By similarity
Binding site2651Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B2UL96 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 1FA51CFF16A29FE7

FASTA31333,127
        10         20         30         40         50         60 
MSDIPSNEQI RTALDNAYAY AKTVQGGKNA SYIPALAQVP SDLLAIAVVT VNGDLLTAGS 

        70         80         90        100        110        120 
ADAPFAIESI SKAFNLAYVM DLIGMKQLRA KIGADPTGEP FNSVMAIELH GGKPLNPLVN 

       130        140        150        160        170        180 
AGAMATVSLV NGSDSDEIWG NMIHNFNNFA NTALTVNQEI YKSESATNQH NRGIAWLLDS 

       190        200        210        220        230        240 
YGYFYNTPPM IVDLYTRMCS LNITASQLAL MGACYANGGV NPVSKKRVVK EENVPPILAE 

       250        260        270        280        290        300 
MCMSGLYDST GDWMYKAGLP AKSGVGGGLV AVAPGKLAMA AFSPPLDPAG NTVKGQAALQ 

       310 
SIIRELNLNL FRS 

« Hide

References

[1]"Complete sequence of Akkermansia muciniphila ATCC BAA-835."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. expand/collapse author list , Smidt H., Derrien M., Plugge C.M., Zoetendal E.G., de Vos W.M., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-835.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001071 Genomic DNA. Translation: ACD03885.1.
RefSeqYP_001876666.1. NC_010655.1.

3D structure databases

ProteinModelPortalB2UL96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349741.Amuc_0038.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD03885; ACD03885; Amuc_0038.
GeneID6275164.
KEGGamu:Amuc_0038.
PATRIC20832542. VBIAkkMuc16855_0044.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAMGLHLMS.
OrthoDBEOG6N94BK.
ProtClustDBPRK12356.

Enzyme and pathway databases

BioCycAMUC349741:GHZ7-40-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_AKKM8
AccessionPrimary (citable) accession number: B2UL96
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families