ID   B2UKZ0_AKKM8            Unreviewed;       258 AA.
AC   B2UKZ0;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Pseudouridine synthase {ECO:0000313|EMBL:ACD05263.1};
GN   OrderedLocusNames=Amuc_1441 {ECO:0000313|EMBL:ACD05263.1};
OS   Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS   81048 / CCUG 64013 / CIP 107961 / Muc).
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05263.1, ECO:0000313|Proteomes:UP000001031};
RN   [1] {ECO:0000313|Proteomes:UP000001031}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC   / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
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DR   EMBL; CP001071; ACD05263.1; -; Genomic_DNA.
DR   RefSeq; WP_012420478.1; NZ_CP071807.1.
DR   AlphaFoldDB; B2UKZ0; -.
DR   STRING; 349741.Amuc_1441; -.
DR   PaxDb; 349741-Amuc_1441; -.
DR   KEGG; amu:Amuc_1441; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_11_3_0; -.
DR   OrthoDB; 9807829at2; -.
DR   BioCyc; AMUC349741:G1GBX-1540-MONOMER; -.
DR   Proteomes; UP000001031; Chromosome.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF93; PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001031}.
FT   DOMAIN          24..185
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
SQ   SEQUENCE   258 AA;  29234 MW;  563A23DA17EEB8A1 CRC64;
     MWIPISEAPI ACFPHFEVAA ESGDWIVVDK GAPLIVHPSN GKKEPCLLEG VEALLSYEIA
     NGAALSLVNR LDRETSGLTL VAKHKRAARE LGRAMQRRLI HKEYLAIVQE WPEWTETACT
     APILRQGEVA ESRIWVKQAV HPAGKACTTV FRKERTWNTR RGPLALVRCI PETGRMHQIR
     VHLAHLGHPI LGDKIYGPSE HCYLEYIQHG WSRELEERLV LPRHALHACR LEFPFDEETF
     TAEAPLPEDM RLLLETGD
//