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B2UKY5

- MDH_AKKM8

UniProt

B2UKY5 - MDH_AKKM8

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Akkermansia muciniphila (strain ATCC BAA-835)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei105 – 1051NADUniRule annotation
Binding sitei112 – 1121NADUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Active sitei187 – 1871Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NADUniRule annotation
Nucleotide bindingi129 – 1313NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAMUC349741:GHZ7-1482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Amuc_1436
OrganismiAkkermansia muciniphila (strain ATCC BAA-835)
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesVerrucomicrobiaceaeAkkermansia
ProteomesiUP000001031: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Malate dehydrogenasePRO_1000191608Add
BLAST

Proteomic databases

PRIDEiB2UKY5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi349741.Amuc_1436.

Structurei

3D structure databases

ProteinModelPortaliB2UKY5.
SMRiB2UKY5. Positions 1-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFSQECI.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UKY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTPITVTVT GAAGQIAYSL LFRIASGSML GPDQPINLRL LEIPPAMNAL
60 70 80 90 100
EGVVMELRDA AFPLVNEIVP TSDPDEAFAG ANWCLLVGSV PRKAGMERKD
110 120 130 140 150
LLDINGKVFI GQGQAIARSA AKDVRVLVVG NPCNTNALIA MHNASGVPSD
160 170 180 190 200
RFFAMTRLDE NRAKSQLAEK AGVHVTEVTN MAIWGNHSST QYPDFTNARI
210 220 230 240 250
GGKPVTEVIK DTEWLKGDFI TTVQQRGAAI IKARGASSAA SAASAAVDTV
260 270 280 290 300
RSLATQTPEG DWYSVAVCSD GSYGIEKGLI CSFPVRTTKD GGWEIVQGLP
310 320
VDAFSREKID ATVNELKEER DAVSSLLKH
Length:329
Mass (Da):35,097
Last modified:July 1, 2008 - v1
Checksum:i4B2DFD6D48B6DA04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD05258.1.
RefSeqiYP_001878039.1. NC_010655.1.

Genome annotation databases

EnsemblBacteriaiACD05258; ACD05258; Amuc_1436.
GeneIDi6274593.
KEGGiamu:Amuc_1436.
PATRICi20835794. VBIAkkMuc16855_1630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA. Translation: ACD05258.1 .
RefSeqi YP_001878039.1. NC_010655.1.

3D structure databases

ProteinModelPortali B2UKY5.
SMRi B2UKY5. Positions 1-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349741.Amuc_1436.

Proteomic databases

PRIDEi B2UKY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD05258 ; ACD05258 ; Amuc_1436 .
GeneIDi 6274593.
KEGGi amu:Amuc_1436.
PATRICi 20835794. VBIAkkMuc16855_1630.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi AFSQECI.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci AMUC349741:GHZ7-1482-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes."
    van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M., Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.
    PLoS ONE 6:E16876-E16876(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-835.

Entry informationi

Entry nameiMDH_AKKM8
AccessioniPrimary (citable) accession number: B2UKY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3