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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Akkermansia muciniphila (strain ATCC BAA-835 / Muc)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno), Enolase (eno)
  5. Pyruvate kinase (Amuc_0431)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei202ATPUniRule annotation1
Binding sitei328ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi354 – 357ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMUC349741:G1GBX-1511-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Amuc_1418
OrganismiAkkermansia muciniphila (strain ATCC BAA-835 / Muc)
Taxonomic identifieri349741 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaVerrucomicrobiaeVerrucomicrobialesAkkermansiaceaeAkkermansia
Proteomesi
  • UP000001031 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000963181 – 403Phosphoglycerate kinaseAdd BLAST403

Proteomic databases

PRIDEiB2UKW8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349741.Amuc_1418

Structurei

3D structure databases

ProteinModelPortaliB2UKW8
SMRiB2UKW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit

Sequencei

Sequence statusi: Complete.

B2UKW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLTVRDLD AKGKEVLMRV DFNVPLKDGE ITNDARIVAA LPTIKFLLDQ
60 70 80 90 100
GARLVLTSHL GRPKNEPDPA FSLKPVAARL SELLGKDVKF VSAAIGPEAE
110 120 130 140 150
AARAAMKDGD VVLLENVRFY PGEKKNDPEF AKSLLGNATL FVNDAFGTAH
160 170 180 190 200
RAHASTEGVT HFAEKSAMGF LIERELEYLE GKLENPEKPF VVIMGGAKVS
210 220 230 240 250
DKIEVLSKLM EKADTFLIGG AMANTFLAAE GYDLGASKIE GDKLDLAREI
260 270 280 290 300
LAAAKAKGVK FLLPADVRVA MKFEDGAETF CTAPFAEGGK VPEGGMAIDI
310 320 330 340 350
GDKAIEEFSA IIKDAKTVLW NGPMGVFEMD CFAKGTKEVA EALADSTAIS
360 370 380 390 400
IVGGGDSVTA AKKFKVQDKL SFCSTGGGAS LELLEGKVLP GVGALTDKCC

CGK
Length:403
Mass (Da):42,692
Last modified:July 1, 2008 - v1
Checksum:iD1C36242537338F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001071 Genomic DNA Translation: ACD05241.1
RefSeqiWP_012420456.1, NC_010655.1

Genome annotation databases

EnsemblBacteriaiACD05241; ACD05241; Amuc_1418
GeneIDi34175653
KEGGiamu:Amuc_1418

Similar proteinsi

Entry informationi

Entry nameiPGK_AKKM8
AccessioniPrimary (citable) accession number: B2UKW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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