ID   B2UI43_RALPJ            Unreviewed;       565 AA.
AC   B2UI43;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACD29244.1};
GN   OrderedLocusNames=Rpic_4143 {ECO:0000313|EMBL:ACD29244.1};
OS   Ralstonia pickettii (strain 12J).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=402626 {ECO:0000313|EMBL:ACD29244.1};
RN   [1] {ECO:0000313|EMBL:ACD29244.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=12J {ECO:0000313|EMBL:ACD29244.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Marsh T., Richardson P.;
RT   "Complete sequence of chromosome2 of Ralstonia pickettii 12J.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP001069; ACD29244.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2UI43; -.
DR   STRING; 402626.Rpic_4143; -.
DR   KEGG; rpi:Rpic_4143; -.
DR   PATRIC; fig|402626.5.peg.390; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_59_10_4; -.
DR   GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR   GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACD29244.1}.
FT   DOMAIN          46..403
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          454..531
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   565 AA;  62417 MW;  4ACEF5F85F548132 CRC64;
     MTSLDAFLRC RDFLLAHRED YDTAVRDFAW PQLDRFNWAL DYFDAMARGN DAVALWVVDD
     QGNETRLSFA QMAERSARVA NHLRALGVQR GDRILLMLGN VPGLWDVMLA SIKIGAVIIP
     ATTLLTAEDL RERIAMGEVS HVVVGGADCA KLDAVSGTFT RIAVGTDKAP AGWHRFEDAY
     DASAEFTPDA PTQASDPLLL YFTSGTTSKP KLVMHTHASY PVGHLSTLYW IGLRPGDVHW
     NISSPGWAKH AWSCFFAPWN AGATVFIYNY ARFEPKAVLD VLCRAKVTTL CAPPTVWRML
     IQEDLAAWKP ALRELVGAGE PLNPEVIERV RAAWGITIRD GYGQTETTCQ IGNSPGQRVQ
     PGSMGRPLPG YRITLRDPDG HEAEEGEICI ELNSRPTGLM EGYAGNADKT AEAMRGGVYH
     TSDIAARDAS GYLTYVGRAD DVFKASDYRV SPFELESVLI EHPAIAEAAV VPSPDPLRLA
     VPKAFLVLRA GHEAGPELAR DILGFCRSRL ASYKRVRRIE FADLPKTISG KIRRVELRMR
     EAARSENTAG VRNLQEYWEE DFPGD
//