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B2UG82

- GCSP_RALPJ

UniProt

B2UG82 - GCSP_RALPJ

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRPIC402626:GH94-3546-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Rpic_3489
    OrganismiRalstonia pickettii (strain 12J)
    Taxonomic identifieri402626 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000002566: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 979979Glycine dehydrogenase (decarboxylating)PRO_1000132447Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi402626.Rpic_3489.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UG82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UG82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAPHPASSA LAAERPTLAD LEARDAFAHR HIGPSADEQT AMLGTLGYTS    50
    RAALIDAVIP PAIRRQDGMP LGEFTQPLTE EAALAKLRGI AGQNRVVKSL 100
    IGQGYYGTHT PGVILRNILE NPAWYTAYTP YQPEISQGRL EAMLNFQQMV 150
    IDLTAMDIAN ASMLDEATAA AEAMTLLQRI GKSKSTVFFV ADDVLPQTLE 200
    VVRTRAEPIG VQVVTGPAAD AAKHDAFGVL LQYPGANGAL LGDLATYQAL 250
    TDAVHAAGGL VVAAADLLAL TLLAAPGEWG ADVVIGNTQR FGVPFGFGGP 300
    HAGYMAVRDA FKRSMPGRLV GVTIDAQGNP AYRLALQTRE QHIRREKATS 350
    NICTAQVLLG VMASMYAVYH GPQGLKRIAQ RVHRLSATLA AGLRAIGYTL 400
    ESDAFFDTLT VVTGPRTANL HIAAQAHGIN LRQIDDARLG ISLDETVTRA 450
    DVVALWEVFA HAAHAAAPDF DQTEAGVADA YPASLVRQSA YLTHPVFNAH 500
    HSEHEMLRYL RSLADKDLAL DRTMIPLGSC TMKLNATAEM LPVTWPEFSN 550
    IHPFAPADQT VGYREMIDQL EQMLCAATGY AAVSLQPNAG SQGEYAGLLI 600
    IHAYHASRGE AHRNVCLIPS SAHGTNPASA QMAGMQVVVV ACDERGNVDL 650
    ADLEKKAAEH SKNLAAIMIT YPSTHGVFEE GVKRVCEIVH SHGGQVYVDG 700
    ANMNAMVGTA APGHFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAP 750
    FLPGRAASGE DASQNIGNVS ASAFGSASIL PISWMYIAMM GAAGLTAATE 800
    TAILSANYVA KRLAPYYPVL YTGAHGLVAH ECILDIRPLQ KESGISNEDI 850
    AKRLMDFGFH APTMSFPVPG TLMIEPTESE PKVELDRFID AMIAIRGEVD 900
    KVISGEFDRE DNPLKHAPHT AAVVMADDWS HKYTREQAAY PVASLRARKY 950
    WPPVGRADNV YGDRNLFCAC VPMSEYAQD 979
    Length:979
    Mass (Da):104,515
    Last modified:July 1, 2008 - v1
    Checksum:i15C07551CAFF0841
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001068 Genomic DNA. Translation: ACD28609.1.
    RefSeqiYP_001901041.1. NC_010682.1.

    Genome annotation databases

    EnsemblBacteriaiACD28609; ACD28609; Rpic_3489.
    GeneIDi6286754.
    KEGGirpi:Rpic_3489.
    PATRICi20257817. VBIRalPic63053_4623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001068 Genomic DNA. Translation: ACD28609.1 .
    RefSeqi YP_001901041.1. NC_010682.1.

    3D structure databases

    ProteinModelPortali B2UG82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402626.Rpic_3489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD28609 ; ACD28609 ; Rpic_3489 .
    GeneIDi 6286754.
    KEGGi rpi:Rpic_3489.
    PATRICi 20257817. VBIRalPic63053_4623.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RPIC402626:GH94-3546-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 12J.

    Entry informationi

    Entry nameiGCSP_RALPJ
    AccessioniPrimary (citable) accession number: B2UG82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3