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B2UG82

- GCSP_RALPJ

UniProt

B2UG82 - GCSP_RALPJ

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRPIC402626:GH94-3546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Rpic_3489
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000002566: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Glycine dehydrogenase (decarboxylating)PRO_1000132447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi402626.Rpic_3489.

Structurei

3D structure databases

ProteinModelPortaliB2UG82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UG82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPHPASSA LAAERPTLAD LEARDAFAHR HIGPSADEQT AMLGTLGYTS
60 70 80 90 100
RAALIDAVIP PAIRRQDGMP LGEFTQPLTE EAALAKLRGI AGQNRVVKSL
110 120 130 140 150
IGQGYYGTHT PGVILRNILE NPAWYTAYTP YQPEISQGRL EAMLNFQQMV
160 170 180 190 200
IDLTAMDIAN ASMLDEATAA AEAMTLLQRI GKSKSTVFFV ADDVLPQTLE
210 220 230 240 250
VVRTRAEPIG VQVVTGPAAD AAKHDAFGVL LQYPGANGAL LGDLATYQAL
260 270 280 290 300
TDAVHAAGGL VVAAADLLAL TLLAAPGEWG ADVVIGNTQR FGVPFGFGGP
310 320 330 340 350
HAGYMAVRDA FKRSMPGRLV GVTIDAQGNP AYRLALQTRE QHIRREKATS
360 370 380 390 400
NICTAQVLLG VMASMYAVYH GPQGLKRIAQ RVHRLSATLA AGLRAIGYTL
410 420 430 440 450
ESDAFFDTLT VVTGPRTANL HIAAQAHGIN LRQIDDARLG ISLDETVTRA
460 470 480 490 500
DVVALWEVFA HAAHAAAPDF DQTEAGVADA YPASLVRQSA YLTHPVFNAH
510 520 530 540 550
HSEHEMLRYL RSLADKDLAL DRTMIPLGSC TMKLNATAEM LPVTWPEFSN
560 570 580 590 600
IHPFAPADQT VGYREMIDQL EQMLCAATGY AAVSLQPNAG SQGEYAGLLI
610 620 630 640 650
IHAYHASRGE AHRNVCLIPS SAHGTNPASA QMAGMQVVVV ACDERGNVDL
660 670 680 690 700
ADLEKKAAEH SKNLAAIMIT YPSTHGVFEE GVKRVCEIVH SHGGQVYVDG
710 720 730 740 750
ANMNAMVGTA APGHFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAP
760 770 780 790 800
FLPGRAASGE DASQNIGNVS ASAFGSASIL PISWMYIAMM GAAGLTAATE
810 820 830 840 850
TAILSANYVA KRLAPYYPVL YTGAHGLVAH ECILDIRPLQ KESGISNEDI
860 870 880 890 900
AKRLMDFGFH APTMSFPVPG TLMIEPTESE PKVELDRFID AMIAIRGEVD
910 920 930 940 950
KVISGEFDRE DNPLKHAPHT AAVVMADDWS HKYTREQAAY PVASLRARKY
960 970
WPPVGRADNV YGDRNLFCAC VPMSEYAQD
Length:979
Mass (Da):104,515
Last modified:July 1, 2008 - v1
Checksum:i15C07551CAFF0841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD28609.1.
RefSeqiYP_001901041.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD28609; ACD28609; Rpic_3489.
GeneIDi6286754.
KEGGirpi:Rpic_3489.
PATRICi20257817. VBIRalPic63053_4623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD28609.1 .
RefSeqi YP_001901041.1. NC_010682.1.

3D structure databases

ProteinModelPortali B2UG82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402626.Rpic_3489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD28609 ; ACD28609 ; Rpic_3489 .
GeneIDi 6286754.
KEGGi rpi:Rpic_3489.
PATRICi 20257817. VBIRalPic63053_4623.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RPIC402626:GH94-3546-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiGCSP_RALPJ
AccessioniPrimary (citable) accession number: B2UG82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3