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B2UG82 (GCSP_RALPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Rpic_3489
OrganismRalstonia pickettii (strain 12J) [Complete proteome] [HAMAP]
Taxonomic identifier402626 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length979 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 979979Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132447

Amino acid modifications

Modified residue7261N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2UG82 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 15C07551CAFF0841

FASTA979104,515
        10         20         30         40         50         60 
MNAPHPASSA LAAERPTLAD LEARDAFAHR HIGPSADEQT AMLGTLGYTS RAALIDAVIP 

        70         80         90        100        110        120 
PAIRRQDGMP LGEFTQPLTE EAALAKLRGI AGQNRVVKSL IGQGYYGTHT PGVILRNILE 

       130        140        150        160        170        180 
NPAWYTAYTP YQPEISQGRL EAMLNFQQMV IDLTAMDIAN ASMLDEATAA AEAMTLLQRI 

       190        200        210        220        230        240 
GKSKSTVFFV ADDVLPQTLE VVRTRAEPIG VQVVTGPAAD AAKHDAFGVL LQYPGANGAL 

       250        260        270        280        290        300 
LGDLATYQAL TDAVHAAGGL VVAAADLLAL TLLAAPGEWG ADVVIGNTQR FGVPFGFGGP 

       310        320        330        340        350        360 
HAGYMAVRDA FKRSMPGRLV GVTIDAQGNP AYRLALQTRE QHIRREKATS NICTAQVLLG 

       370        380        390        400        410        420 
VMASMYAVYH GPQGLKRIAQ RVHRLSATLA AGLRAIGYTL ESDAFFDTLT VVTGPRTANL 

       430        440        450        460        470        480 
HIAAQAHGIN LRQIDDARLG ISLDETVTRA DVVALWEVFA HAAHAAAPDF DQTEAGVADA 

       490        500        510        520        530        540 
YPASLVRQSA YLTHPVFNAH HSEHEMLRYL RSLADKDLAL DRTMIPLGSC TMKLNATAEM 

       550        560        570        580        590        600 
LPVTWPEFSN IHPFAPADQT VGYREMIDQL EQMLCAATGY AAVSLQPNAG SQGEYAGLLI 

       610        620        630        640        650        660 
IHAYHASRGE AHRNVCLIPS SAHGTNPASA QMAGMQVVVV ACDERGNVDL ADLEKKAAEH 

       670        680        690        700        710        720 
SKNLAAIMIT YPSTHGVFEE GVKRVCEIVH SHGGQVYVDG ANMNAMVGTA APGHFGGDVS 

       730        740        750        760        770        780 
HLNLHKTFCI PHGGGGPGVG PVAVGAHLAP FLPGRAASGE DASQNIGNVS ASAFGSASIL 

       790        800        810        820        830        840 
PISWMYIAMM GAAGLTAATE TAILSANYVA KRLAPYYPVL YTGAHGLVAH ECILDIRPLQ 

       850        860        870        880        890        900 
KESGISNEDI AKRLMDFGFH APTMSFPVPG TLMIEPTESE PKVELDRFID AMIAIRGEVD 

       910        920        930        940        950        960 
KVISGEFDRE DNPLKHAPHT AAVVMADDWS HKYTREQAAY PVASLRARKY WPPVGRADNV 

       970 
YGDRNLFCAC VPMSEYAQD 

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References

[1]"Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 12J.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001068 Genomic DNA. Translation: ACD28609.1.
RefSeqYP_001901041.1. NC_010682.1.

3D structure databases

ProteinModelPortalB2UG82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402626.Rpic_3489.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD28609; ACD28609; Rpic_3489.
GeneID6286754.
KEGGrpi:Rpic_3489.
PATRIC20257817. VBIRalPic63053_4623.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycRPIC402626:GH94-3546-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RALPJ
AccessionPrimary (citable) accession number: B2UG82
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families