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B2UG82

- GCSP_RALPJ

UniProt

B2UG82 - GCSP_RALPJ

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Rpic_3489
Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRPIC402626:GH94-3546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Rpic_3489
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000002566: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi402626.Rpic_3489.

Structurei

3D structure databases

ProteinModelPortaliB2UG82.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UG82-1 [UniParc]FASTAAdd to Basket

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MNAPHPASSA LAAERPTLAD LEARDAFAHR HIGPSADEQT AMLGTLGYTS    50
RAALIDAVIP PAIRRQDGMP LGEFTQPLTE EAALAKLRGI AGQNRVVKSL 100
IGQGYYGTHT PGVILRNILE NPAWYTAYTP YQPEISQGRL EAMLNFQQMV 150
IDLTAMDIAN ASMLDEATAA AEAMTLLQRI GKSKSTVFFV ADDVLPQTLE 200
VVRTRAEPIG VQVVTGPAAD AAKHDAFGVL LQYPGANGAL LGDLATYQAL 250
TDAVHAAGGL VVAAADLLAL TLLAAPGEWG ADVVIGNTQR FGVPFGFGGP 300
HAGYMAVRDA FKRSMPGRLV GVTIDAQGNP AYRLALQTRE QHIRREKATS 350
NICTAQVLLG VMASMYAVYH GPQGLKRIAQ RVHRLSATLA AGLRAIGYTL 400
ESDAFFDTLT VVTGPRTANL HIAAQAHGIN LRQIDDARLG ISLDETVTRA 450
DVVALWEVFA HAAHAAAPDF DQTEAGVADA YPASLVRQSA YLTHPVFNAH 500
HSEHEMLRYL RSLADKDLAL DRTMIPLGSC TMKLNATAEM LPVTWPEFSN 550
IHPFAPADQT VGYREMIDQL EQMLCAATGY AAVSLQPNAG SQGEYAGLLI 600
IHAYHASRGE AHRNVCLIPS SAHGTNPASA QMAGMQVVVV ACDERGNVDL 650
ADLEKKAAEH SKNLAAIMIT YPSTHGVFEE GVKRVCEIVH SHGGQVYVDG 700
ANMNAMVGTA APGHFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAP 750
FLPGRAASGE DASQNIGNVS ASAFGSASIL PISWMYIAMM GAAGLTAATE 800
TAILSANYVA KRLAPYYPVL YTGAHGLVAH ECILDIRPLQ KESGISNEDI 850
AKRLMDFGFH APTMSFPVPG TLMIEPTESE PKVELDRFID AMIAIRGEVD 900
KVISGEFDRE DNPLKHAPHT AAVVMADDWS HKYTREQAAY PVASLRARKY 950
WPPVGRADNV YGDRNLFCAC VPMSEYAQD 979
Length:979
Mass (Da):104,515
Last modified:July 1, 2008 - v1
Checksum:i15C07551CAFF0841
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD28609.1.
RefSeqiYP_001901041.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD28609; ACD28609; Rpic_3489.
GeneIDi6286754.
KEGGirpi:Rpic_3489.
PATRICi20257817. VBIRalPic63053_4623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD28609.1 .
RefSeqi YP_001901041.1. NC_010682.1.

3D structure databases

ProteinModelPortali B2UG82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402626.Rpic_3489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD28609 ; ACD28609 ; Rpic_3489 .
GeneIDi 6286754.
KEGGi rpi:Rpic_3489.
PATRICi 20257817. VBIRalPic63053_4623.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RPIC402626:GH94-3546-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiGCSP_RALPJ
AccessioniPrimary (citable) accession number: B2UG82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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