Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2UG80 (GCST_RALPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminomethyltransferase

EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:Rpic_3487
OrganismRalstonia pickettii (strain 12J) [Complete proteome] [HAMAP]
Taxonomic identifier402626 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP-Rule MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP-Rule MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminomethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Aminomethyltransferase HAMAP-Rule MF_00259
PRO_1000114108

Sequences

Sequence LengthMass (Da)Tools
B2UG80 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 6E8CAE7C9F89D7CA

FASTA37540,148
        10         20         30         40         50         60 
MTLQHTPLNA IHRSLGARMV DFGGWDMPVN YGSQIEEHHA VRQDAGVFDV SHMCVVDLTG 

        70         80         90        100        110        120 
ARVRDFLRGL LANNVDKLQT PGKALYSCML NPKGGVIDDL IVYFFREDWF RLVVNAGTAP 

       130        140        150        160        170        180 
TDLEWIVAQN AAAGTDVTIT PRRSDNNAGA EPLGILAVQG PNARAKTYAA LPGSQAVGDA 

       190        200        210        220        230        240 
LKPFNAGFVT VENVGEIMVA RTGYTGEDGF ELVVPAAQIA GVWERLLQAG VRPAGLGARD 

       250        260        270        280        290        300 
TLRLEAGMNL YGQDMDEHVS PLDAGLAWTV DLQSERDFTG KAALQAGGQR EQFVGLILRD 

       310        320        330        340        350        360 
KGGVLRAHQK VITAAGDGEI TSGTFSPSLS LSIALARLPK EVPVGTDVQV EIRDRKLTAT 

       370 
VVKLPFVRNG KALVS 

« Hide

References

[1]"Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 12J.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001068 Genomic DNA. Translation: ACD28607.1.
RefSeqYP_001901039.1. NC_010682.1.

3D structure databases

ProteinModelPortalB2UG80.
SMRB2UG80. Positions 5-373.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402626.Rpic_3487.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD28607; ACD28607; Rpic_3487.
GeneID6286303.
KEGGrpi:Rpic_3487.
PATRIC20257813. VBIRalPic63053_4621.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0404.
HOGENOMHOG000239381.
KOK00605.
OMAPFFGVQS.
OrthoDBEOG6T1WS5.

Enzyme and pathway databases

BioCycRPIC402626:GH94-3544-MONOMER.

Family and domain databases

Gene3D2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPMF_00259. GcvT.
InterProIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
SUPFAMSSF101790. SSF101790. 1 hit.
TIGRFAMsTIGR00528. gcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_RALPJ
AccessionPrimary (citable) accession number: B2UG80
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families