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B2UCA1

- SYL_RALPJ

UniProt

B2UCA1 - SYL_RALPJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPIC402626:GH94-3022-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Rpic_2983
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000002566: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877Leucine--tRNA ligasePRO_1000091349Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402626.Rpic_2983.

Structurei

3D structure databases

ProteinModelPortaliB2UCA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi636 – 6405"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2UCA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDKYSPSDV EQQAQQHWQA LDAYRVTEHA RAADGSDKPK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDVMTR QLRMKGYNVL MPMGWDAFGM PAENAALNNG
110 120 130 140 150
VAPAAWTYDN IAYMKKQMQS MGLAIDWSRE VATCSPDYYR WNQWLFLKML
160 170 180 190 200
EKGIAYRKTG TVNWDPVDQT VLANEQVIDG RGWRSGAVVE KREIPMYYLG
210 220 230 240 250
ITKYAQELLS DLDPLGWPER VKLMQQNWIG KSEGVRFAFP HNISGDDGKL
260 270 280 290 300
INDGKLYVFT TRADTIMGVT FCAVAAEHPI ATHAAQSNPA LAAFIEECKH
310 320 330 340 350
GSVMEADMAT MEKKGMPTGL TVTHPLTGES VPVWVGNYVL MTYGDGAVMG
360 370 380 390 400
VPAHDERDFA FANKYHLPIK QVIDVKGQSY DTTTWADWYG DKEHGVLFHS
410 420 430 440 450
GKYDGLNYQQ AVDAVAADLA AQGLGEKKTT WRLRDWGISR QRYWGTPIPL
460 470 480 490 500
IHCESCGVVP VPEQDLPVRL PEDLVPDGTG NPLAKDPRFL NCTCPSCGKP
510 520 530 540 550
ARRETDTMDT FIDSCWYYMR YTCPDGETMV DARNDYWMPM DQYIGGIEHA
560 570 580 590 600
ILHLLYARFW TKVMRDLGLV KFDEPFTNLL TQGMVLNETY YREDASGKKQ
610 620 630 640 650
WINPADVDVQ TDERGRPVGA TLKADGQPVV IGGVEKMSKS KNNGIDPQAL
660 670 680 690 700
IDQYGADTAR LFTMFAAPPE QQLEWNDAGV EGASRFLRRL WNFGVVHGDA
710 720 730 740 750
IRGGHGNGVV AGATDADRAL RRELYTVLKQ ANYDYERLQY NTVVSATMKM
760 770 780 790 800
LNALEGAKDA GADARREGLG LLLRVLYPVV PHITHVLWTE LGYAGAYGDL
810 820 830 840 850
LDAPWPQVDE GALVQSEIEL VLQVNGKVRG SIVVPADADR AAIEAIAAKD
860 870
EAVQKFAEGK PPKKIIVVPG RLVNVVA
Length:877
Mass (Da):97,691
Last modified:July 1, 2008 - v1
Checksum:iF3F20541DD6871B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD28106.1.
RefSeqiYP_001900538.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD28106; ACD28106; Rpic_2983.
GeneIDi6289706.
KEGGirpi:Rpic_2983.
PATRICi20256773. VBIRalPic63053_4119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD28106.1 .
RefSeqi YP_001900538.1. NC_010682.1.

3D structure databases

ProteinModelPortali B2UCA1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402626.Rpic_2983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD28106 ; ACD28106 ; Rpic_2983 .
GeneIDi 6289706.
KEGGi rpi:Rpic_2983.
PATRICi 20256773. VBIRalPic63053_4119.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RPIC402626:GH94-3022-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiSYL_RALPJ
AccessioniPrimary (citable) accession number: B2UCA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3