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B2UBA3

- ASSY_RALPJ

UniProt

B2UBA3 - ASSY_RALPJ

Protein

Argininosuccinate synthase

Gene

argG

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPUniRule annotation
    Binding sitei99 – 991CitrullineUniRule annotation
    Binding sitei129 – 1291ATP; via amide nitrogenUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei131 – 1311ATPUniRule annotation
    Binding sitei135 – 1351AspartateUniRule annotation
    Binding sitei135 – 1351CitrullineUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361ATPUniRule annotation
    Binding sitei139 – 1391CitrullineUniRule annotation
    Binding sitei192 – 1921CitrullineUniRule annotation
    Binding sitei194 – 1941ATPUniRule annotation
    Binding sitei201 – 2011CitrullineUniRule annotation
    Binding sitei203 – 2031CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRPIC402626:GH94-2868-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Rpic_2829
    OrganismiRalstonia pickettii (strain 12J)
    Taxonomic identifieri402626 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000002566: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Argininosuccinate synthasePRO_1000129760Add
    BLAST

    Proteomic databases

    PRIDEiB2UBA3.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi402626.Rpic_2829.

    Structurei

    3D structure databases

    ProteinModelPortaliB2UBA3.
    SMRiB2UBA3. Positions 3-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2UBA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    METILQHVPV GQKVGIAFSG GLDTSAALRW MKNKGALPYA YTANLGQPDE    50
    EDYDAIPRKA MEYGAEKARL IDCRPQLANE GIAAIQSGAF HISTGGITYF 100
    NTTPLGRAVT GTMLVAAMKE DDVNIWGDGS TFKGNDIERF YRYGLLTNPA 150
    LKIYKPWLDQ AFIDELGGRA EMSAFMTKEG FGYKMSAEKA YSTDSNMLGA 200
    THEAKDLEHL NSGIRIVNPI MGVAFWKPEV EVKAEEVSIT FDEGRPVAVN 250
    GREIADPVEM FLELNRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    HIAYERLVTG IHNEDTIEQY RINGLRLGRL LYQGRWFDPQ AIMLRETAQR 350
    WVARAVTGTV TLELRRGNDY SILNTESPNL TYAPERLSME KVEDAPFSPA 400
    DRIGQLTMRN LDLMDTRDKL AIYSKAGLLS LGTANALPQL DGGKK 445
    Length:445
    Mass (Da):49,292
    Last modified:July 1, 2008 - v1
    Checksum:i63F56DB32F7BDE4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001068 Genomic DNA. Translation: ACD27952.1.
    RefSeqiYP_001900384.1. NC_010682.1.

    Genome annotation databases

    EnsemblBacteriaiACD27952; ACD27952; Rpic_2829.
    GeneIDi6287501.
    KEGGirpi:Rpic_2829.
    PATRICi20256467. VBIRalPic63053_3966.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001068 Genomic DNA. Translation: ACD27952.1 .
    RefSeqi YP_001900384.1. NC_010682.1.

    3D structure databases

    ProteinModelPortali B2UBA3.
    SMRi B2UBA3. Positions 3-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402626.Rpic_2829.

    Proteomic databases

    PRIDEi B2UBA3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD27952 ; ACD27952 ; Rpic_2829 .
    GeneIDi 6287501.
    KEGGi rpi:Rpic_2829.
    PATRICi 20256467. VBIRalPic63053_3966.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci RPIC402626:GH94-2868-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 12J.

    Entry informationi

    Entry nameiASSY_RALPJ
    AccessioniPrimary (citable) accession number: B2UBA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3