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B2UAP5

- NADA_RALPJ

UniProt

B2UAP5 - NADA_RALPJ

Protein

Quinolinate synthase A

Gene

nadA

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

    Catalytic activityi

    Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631IminoaspartateUniRule annotation
    Binding sitei84 – 841Iminoaspartate; via amide nitrogenUniRule annotation
    Binding sitei155 – 1551IminoaspartateUniRule annotation
    Binding sitei172 – 1721IminoaspartateUniRule annotation
    Binding sitei242 – 2421IminoaspartateUniRule annotation
    Binding sitei259 – 2591IminoaspartateUniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
    4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciRPIC402626:GH94-2756-MONOMER.
    UniPathwayiUPA00253; UER00327.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
    Gene namesi
    Name:nadAUniRule annotation
    Ordered Locus Names:Rpic_2717
    OrganismiRalstonia pickettii (strain 12J)
    Taxonomic identifieri402626 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000002566: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Quinolinate synthase APRO_1000129421Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi402626.Rpic_2717.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0379.
    HOGENOMiHOG000222769.
    KOiK03517.
    OMAiKTVLMPT.
    OrthoDBiEOG6DJZ56.

    Family and domain databases

    HAMAPiMF_00567. NadA_type1.
    InterProiIPR003473. NadA.
    IPR023513. Quinolinate_synth_A_type1.
    [Graphical view]
    PfamiPF02445. NadA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00550. nadA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2UAP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    METHIKTVEF ERPDMLSEAQ SGASCVAHAW AKVPPVLSRE ERDELKARIK    50
    RLLKEREAVL VAHYYVDADL QDLAEETGGC VSDSLEMARF GRDHSAKTLI 100
    VAGVRFMGET AKILSPEKTV LMPDLDATCS LDLGCPPDEF AAFCDAHPDR 150
    TVVVYANTSA AVKARADWMV TSSIGLKIVQ HLHAQGKKIL WAPDRHLGSY 200
    IQKQTGADML MWQGSCLVHD EFKGVELDLL RAEHPNAKIL VHPESPESVV 250
    AQADVVGSTS QLIAAAQSLS AQEFIVATDN GILHKMRMAA PGKRFIEAPT 300
    AGNAATCKSC AHCPWMAMNA LTNLAEVLET GRNEIHVDPA IGRQAVVCID 350
    RMLDFAAREK ATVRPQGDLA ANAQLFQGIG PA 382
    Length:382
    Mass (Da):41,479
    Last modified:July 1, 2008 - v1
    Checksum:iF30923B3576E56A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001068 Genomic DNA. Translation: ACD27842.1.
    RefSeqiYP_001900274.1. NC_010682.1.

    Genome annotation databases

    EnsemblBacteriaiACD27842; ACD27842; Rpic_2717.
    GeneIDi6289101.
    KEGGirpi:Rpic_2717.
    PATRICi20256240. VBIRalPic63053_3853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001068 Genomic DNA. Translation: ACD27842.1 .
    RefSeqi YP_001900274.1. NC_010682.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402626.Rpic_2717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD27842 ; ACD27842 ; Rpic_2717 .
    GeneIDi 6289101.
    KEGGi rpi:Rpic_2717.
    PATRICi 20256240. VBIRalPic63053_3853.

    Phylogenomic databases

    eggNOGi COG0379.
    HOGENOMi HOG000222769.
    KOi K03517.
    OMAi KTVLMPT.
    OrthoDBi EOG6DJZ56.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00327 .
    BioCyci RPIC402626:GH94-2756-MONOMER.

    Family and domain databases

    HAMAPi MF_00567. NadA_type1.
    InterProi IPR003473. NadA.
    IPR023513. Quinolinate_synth_A_type1.
    [Graphical view ]
    Pfami PF02445. NadA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00550. nadA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 12J.

    Entry informationi

    Entry nameiNADA_RALPJ
    AccessioniPrimary (citable) accession number: B2UAP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3