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B2UAP5

- NADA_RALPJ

UniProt

B2UAP5 - NADA_RALPJ

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Protein
Quinolinate synthase A
Gene
nadA, Rpic_2717
Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Iminoaspartate By similarity
Binding sitei84 – 841Iminoaspartate; via amide nitrogen By similarity
Binding sitei155 – 1551Iminoaspartate By similarity
Binding sitei172 – 1721Iminoaspartate By similarity
Binding sitei242 – 2421Iminoaspartate By similarity
Binding sitei259 – 2591Iminoaspartate By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. quinolinate synthetase A activity Source: UniProtKB-HAMAP
  4. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciRPIC402626:GH94-2756-MONOMER.
UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase A (EC:2.5.1.72)
Gene namesi
Name:nadA
Ordered Locus Names:Rpic_2717
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000002566: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Quinolinate synthase AUniRule annotation
PRO_1000129421Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi402626.Rpic_2717.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0379.
HOGENOMiHOG000222769.
KOiK03517.
OMAiKTVLMPT.
OrthoDBiEOG6DJZ56.

Family and domain databases

HAMAPiMF_00567. NadA_type1.
InterProiIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2UAP5-1 [UniParc]FASTAAdd to Basket

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METHIKTVEF ERPDMLSEAQ SGASCVAHAW AKVPPVLSRE ERDELKARIK    50
RLLKEREAVL VAHYYVDADL QDLAEETGGC VSDSLEMARF GRDHSAKTLI 100
VAGVRFMGET AKILSPEKTV LMPDLDATCS LDLGCPPDEF AAFCDAHPDR 150
TVVVYANTSA AVKARADWMV TSSIGLKIVQ HLHAQGKKIL WAPDRHLGSY 200
IQKQTGADML MWQGSCLVHD EFKGVELDLL RAEHPNAKIL VHPESPESVV 250
AQADVVGSTS QLIAAAQSLS AQEFIVATDN GILHKMRMAA PGKRFIEAPT 300
AGNAATCKSC AHCPWMAMNA LTNLAEVLET GRNEIHVDPA IGRQAVVCID 350
RMLDFAAREK ATVRPQGDLA ANAQLFQGIG PA 382
Length:382
Mass (Da):41,479
Last modified:July 1, 2008 - v1
Checksum:iF30923B3576E56A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD27842.1.
RefSeqiYP_001900274.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD27842; ACD27842; Rpic_2717.
GeneIDi6289101.
KEGGirpi:Rpic_2717.
PATRICi20256240. VBIRalPic63053_3853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD27842.1 .
RefSeqi YP_001900274.1. NC_010682.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402626.Rpic_2717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD27842 ; ACD27842 ; Rpic_2717 .
GeneIDi 6289101.
KEGGi rpi:Rpic_2717.
PATRICi 20256240. VBIRalPic63053_3853.

Phylogenomic databases

eggNOGi COG0379.
HOGENOMi HOG000222769.
KOi K03517.
OMAi KTVLMPT.
OrthoDBi EOG6DJZ56.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00327 .
BioCyci RPIC402626:GH94-2756-MONOMER.

Family and domain databases

HAMAPi MF_00567. NadA_type1.
InterProi IPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view ]
Pfami PF02445. NadA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00550. nadA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiNADA_RALPJ
AccessioniPrimary (citable) accession number: B2UAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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