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Protein

Quinolinate synthase A

Gene

nadA

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63IminoaspartateUniRule annotation1
Binding sitei84Iminoaspartate; via amide nitrogenUniRule annotation1
Binding sitei155IminoaspartateUniRule annotation1
Binding sitei172IminoaspartateUniRule annotation1
Binding sitei242IminoaspartateUniRule annotation1
Binding sitei259IminoaspartateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyridine nucleotide biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:Rpic_2717
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000002566 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294211 – 382Quinolinate synthase AAdd BLAST382

Proteomic databases

PRIDEiB2UAP5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi402626.Rpic_2717

Structurei

3D structure databases

SMRiB2UAP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0I Bacteria
COG0379 LUCA
HOGENOMiHOG000222769
KOiK03517
OMAiLWAPDRH

Family and domain databases

HAMAPiMF_00567 NadA_type1, 1 hit
InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
IPR023513 Quinolinate_synth_A_type1
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

B2UAP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METHIKTVEF ERPDMLSEAQ SGASCVAHAW AKVPPVLSRE ERDELKARIK
60 70 80 90 100
RLLKEREAVL VAHYYVDADL QDLAEETGGC VSDSLEMARF GRDHSAKTLI
110 120 130 140 150
VAGVRFMGET AKILSPEKTV LMPDLDATCS LDLGCPPDEF AAFCDAHPDR
160 170 180 190 200
TVVVYANTSA AVKARADWMV TSSIGLKIVQ HLHAQGKKIL WAPDRHLGSY
210 220 230 240 250
IQKQTGADML MWQGSCLVHD EFKGVELDLL RAEHPNAKIL VHPESPESVV
260 270 280 290 300
AQADVVGSTS QLIAAAQSLS AQEFIVATDN GILHKMRMAA PGKRFIEAPT
310 320 330 340 350
AGNAATCKSC AHCPWMAMNA LTNLAEVLET GRNEIHVDPA IGRQAVVCID
360 370 380
RMLDFAAREK ATVRPQGDLA ANAQLFQGIG PA
Length:382
Mass (Da):41,479
Last modified:July 1, 2008 - v1
Checksum:iF30923B3576E56A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA Translation: ACD27842.1
RefSeqiWP_012436249.1, NC_010682.1

Genome annotation databases

EnsemblBacteriaiACD27842; ACD27842; Rpic_2717
GeneIDi6289101
KEGGirpi:Rpic_2717
PATRICifig|402626.5.peg.3853

Similar proteinsi

Entry informationi

Entry nameiNADA_RALPJ
AccessioniPrimary (citable) accession number: B2UAP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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