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B2UAP5 (NADA_RALPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Quinolinate synthase A

EC=2.5.1.72
Gene names
Name:nadA
Ordered Locus Names:Rpic_2717
OrganismRalstonia pickettii (strain 12J) [Complete proteome] [HAMAP]
Taxonomic identifier402626 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate By similarity. HAMAP-Rule MF_00567

Catalytic activity

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate. HAMAP-Rule MF_00567

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP-Rule MF_00567

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. HAMAP-Rule MF_00567

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00567

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00567.

Sequence similarities

Belongs to the quinolinate synthase A family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Quinolinate synthase A HAMAP-Rule MF_00567
PRO_1000129421

Sites

Binding site631Iminoaspartate By similarity
Binding site841Iminoaspartate; via amide nitrogen By similarity
Binding site1551Iminoaspartate By similarity
Binding site1721Iminoaspartate By similarity
Binding site2421Iminoaspartate By similarity
Binding site2591Iminoaspartate By similarity

Sequences

Sequence LengthMass (Da)Tools
B2UAP5 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: F30923B3576E56A5

FASTA38241,479
        10         20         30         40         50         60 
METHIKTVEF ERPDMLSEAQ SGASCVAHAW AKVPPVLSRE ERDELKARIK RLLKEREAVL 

        70         80         90        100        110        120 
VAHYYVDADL QDLAEETGGC VSDSLEMARF GRDHSAKTLI VAGVRFMGET AKILSPEKTV 

       130        140        150        160        170        180 
LMPDLDATCS LDLGCPPDEF AAFCDAHPDR TVVVYANTSA AVKARADWMV TSSIGLKIVQ 

       190        200        210        220        230        240 
HLHAQGKKIL WAPDRHLGSY IQKQTGADML MWQGSCLVHD EFKGVELDLL RAEHPNAKIL 

       250        260        270        280        290        300 
VHPESPESVV AQADVVGSTS QLIAAAQSLS AQEFIVATDN GILHKMRMAA PGKRFIEAPT 

       310        320        330        340        350        360 
AGNAATCKSC AHCPWMAMNA LTNLAEVLET GRNEIHVDPA IGRQAVVCID RMLDFAAREK 

       370        380 
ATVRPQGDLA ANAQLFQGIG PA 

« Hide

References

[1]"Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 12J.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001068 Genomic DNA. Translation: ACD27842.1.
RefSeqYP_001900274.1. NC_010682.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402626.Rpic_2717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD27842; ACD27842; Rpic_2717.
GeneID6289101.
KEGGrpi:Rpic_2717.
PATRIC20256240. VBIRalPic63053_3853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0379.
HOGENOMHOG000222769.
KOK03517.
OMAKTVLMPT.
OrthoDBEOG6DJZ56.

Enzyme and pathway databases

BioCycRPIC402626:GH94-2756-MONOMER.
UniPathwayUPA00253; UER00327.

Family and domain databases

HAMAPMF_00567. NadA_type1.
InterProIPR003473. NadA.
IPR023513. Quinolinate_synth_A_type1.
[Graphical view]
PfamPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00550. nadA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADA_RALPJ
AccessionPrimary (citable) accession number: B2UAP5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways