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B2U8V2

- PNCB_RALPJ

UniProt

B2U8V2 - PNCB_RALPJ

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciRPIC402626:GH94-902-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Rpic_0896
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000002566: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Nicotinate phosphoribosyltransferasePRO_1000129479Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402626.Rpic_0896.

Structurei

3D structure databases

ProteinModelPortaliB2U8V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B2U8V2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIRSLLDTD LYKFTMMQVV LHHFPGAHVE YRFKCRNAGV DLVPFIEEIR
60 70 80 90 100
AEIRHLCTLR FTDTELDYLR GMRFIKSDFV DFLGLFHLNE KYIDVRPAPS
110 120 130 140 150
NDGQIEIVIA GPWLHTIMFE VPVLAIVNEV FFSRTQTHPQ WEEGKRRLTD
160 170 180 190 200
KLASLKRPGL EDCRIADYGT RRRFSHTWHE HVLLETHAQL GAQYAGTSNV
210 220 230 240 250
YFAMKHGMTP LGTMAHEYLQ ACQALGPRLR DSQTFALETW AKEYRGDLGI
260 270 280 290 300
ALSDTYGFDA FLRDFDMFFC KLFDGVRHDS GDPFEWGERM LKHYDDMRAE
310 320 330 340 350
PKSKALIFSD SLDMPKVIGL YERFHGRCKL AFGVGTNLTN DLGYTPLQIV
360 370 380
IKIVRCNGQP VAKLSDAPEK TMCDDPAYLT YLKQVFGVQ
Length:389
Mass (Da):44,841
Last modified:July 1, 2008 - v1
Checksum:iDAD25AA8D17CDEDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD26046.1.
RefSeqiYP_001898478.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD26046; ACD26046; Rpic_0896.
GeneIDi6287448.
KEGGirpi:Rpic_0896.
PATRICi20252664. VBIRalPic63053_2096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD26046.1 .
RefSeqi YP_001898478.1. NC_010682.1.

3D structure databases

ProteinModelPortali B2U8V2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402626.Rpic_0896.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD26046 ; ACD26046 ; Rpic_0896 .
GeneIDi 6287448.
KEGGi rpi:Rpic_0896.
PATRICi 20252664. VBIRalPic63053_2096.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci RPIC402626:GH94-902-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiPNCB_RALPJ
AccessioniPrimary (citable) accession number: B2U8V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3