B2U8V2 (PNCB_RALPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	Rpic_0896

Organism

Ralstonia pickettii (strain 12J) [Complete proteome] [HAMAP]

Taxonomic identifier

402626 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_1000129479

Sequences

	Sequence		Length	Mass (Da)
	B2U8V2 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: DAD25AA8D17CDEDF	FASTA	389	44,841
	10 20 30 40 50 60 MIIRSLLDTD LYKFTMMQVV LHHFPGAHVE YRFKCRNAGV DLVPFIEEIR AEIRHLCTLR 70 80 90 100 110 120 FTDTELDYLR GMRFIKSDFV DFLGLFHLNE KYIDVRPAPS NDGQIEIVIA GPWLHTIMFE 130 140 150 160 170 180 VPVLAIVNEV FFSRTQTHPQ WEEGKRRLTD KLASLKRPGL EDCRIADYGT RRRFSHTWHE 190 200 210 220 230 240 HVLLETHAQL GAQYAGTSNV YFAMKHGMTP LGTMAHEYLQ ACQALGPRLR DSQTFALETW 250 260 270 280 290 300 AKEYRGDLGI ALSDTYGFDA FLRDFDMFFC KLFDGVRHDS GDPFEWGERM LKHYDDMRAE 310 320 330 340 350 360 PKSKALIFSD SLDMPKVIGL YERFHGRCKL AFGVGTNLTN DLGYTPLQIV IKIVRCNGQP 370 380 VAKLSDAPEK TMCDDPAYLT YLKQVFGVQ

References

[1]

"Complete sequence of chromosome 1 of Ralstonia pickettii 12J." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Marsh T., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12J.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001068 Genomic DNA. Translation: ACD26046.1.
RefSeq	YP_001898478.1. NC_010682.1.
3D structure databases
ProteinModelPortal	B2U8V2.
ModBase	Search...
Protein-protein interaction databases
STRING	B2U8V2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6287448.
GenomeReviews	Gene locus Rpic_0896 in contig CP001068_GR.
KEGG	rpi:Rpic_0896.
PATRIC	20252664. VBIRalPic63053_2096.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG325503.
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
KO	K00763.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_RALPJ

Accession

Primary (citable) accession number: B2U8V2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program