B2U7J9 (KYNB_RALPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Rpic_0710

Organism

Ralstonia pickettii (strain 12J) [Complete proteome] [HAMAP]

Taxonomic identifier

402626 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362136

Sequences

	Sequence		Length	Mass (Da)
	B2U7J9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: E1FE20258BCF93A3	FASTA	209	22,373
	10 20 30 40 50 60 MERTLWDITP ALSPTTPTWP GDTPFSQEIA WKLEGDCPVN VGRITLSPHT GAHADAPLHY 70 80 90 100 110 120 RADGAAIGQV PLDAYLGLCR VIHCVGVARV EPEHVRDALT NAPPRVLLRT YAHMPQTAWD 130 140 150 160 170 180 NDFAAVAPET IALLATHGVK LIGVDTASLD PQTSKTMDAH HAVGKHGLAI LEGLLLDDVP 190 200 AGDYELIALP LKFATLDASP VRAVLRSLP

References

[1]

"Complete sequence of chromosome 1 of Ralstonia pickettii 12J." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Marsh T., Richardson P. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12J.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001068 Genomic DNA. Translation: ACD25861.1.
RefSeq	YP_001898293.1. NC_010682.1.
3D structure databases
ProteinModelPortal	B2U7J9.
ModBase	Search...
Protein-protein interaction databases
STRING	B2U7J9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6289492.
GenomeReviews	Gene locus Rpic_0710 in contig CP001068_GR.
KEGG	rpi:Rpic_0710.
PATRIC	20252284. VBIRalPic63053_1908.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK2302456.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_RALPJ

Accession

Primary (citable) accession number: B2U7J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program