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Protein

Kynurenine formamidase

Gene

kynB

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tryptophan catabolism

Enzyme and pathway databases

BioCyciRPIC402626:GH94-713-MONOMER.
UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:Rpic_0710
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000002566 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Kynurenine formamidasePRO_0000362136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402626.Rpic_0710.

Structurei

3D structure databases

ProteinModelPortaliB2U7J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107VWA. Bacteria.
COG1878. LUCA.
HOGENOMiHOG000219455.
KOiK07130.
OMAiMDAHHRI.
OrthoDBiEOG67T5JJ.

Family and domain databases

HAMAPiMF_01969. KynB.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

B2U7J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTLWDITP ALSPTTPTWP GDTPFSQEIA WKLEGDCPVN VGRITLSPHT
60 70 80 90 100
GAHADAPLHY RADGAAIGQV PLDAYLGLCR VIHCVGVARV EPEHVRDALT
110 120 130 140 150
NAPPRVLLRT YAHMPQTAWD NDFAAVAPET IALLATHGVK LIGVDTASLD
160 170 180 190 200
PQTSKTMDAH HAVGKHGLAI LEGLLLDDVP AGDYELIALP LKFATLDASP

VRAVLRSLP
Length:209
Mass (Da):22,373
Last modified:July 1, 2008 - v1
Checksum:iE1FE20258BCF93A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD25861.1.
RefSeqiWP_012435090.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD25861; ACD25861; Rpic_0710.
GeneIDi6289492.
KEGGirpi:Rpic_0710.
PATRICi20252284. VBIRalPic63053_1908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD25861.1.
RefSeqiWP_012435090.1. NC_010682.1.

3D structure databases

ProteinModelPortaliB2U7J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402626.Rpic_0710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD25861; ACD25861; Rpic_0710.
GeneIDi6289492.
KEGGirpi:Rpic_0710.
PATRICi20252284. VBIRalPic63053_1908.

Phylogenomic databases

eggNOGiENOG4107VWA. Bacteria.
COG1878. LUCA.
HOGENOMiHOG000219455.
KOiK07130.
OMAiMDAHHRI.
OrthoDBiEOG67T5JJ.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.
BioCyciRPIC402626:GH94-713-MONOMER.

Family and domain databases

HAMAPiMF_01969. KynB.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiKYNB_RALPJ
AccessioniPrimary (citable) accession number: B2U7J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 1, 2008
Last modified: November 11, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.