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B2U7E0

- UPPP_RALPJ

UniProt

B2U7E0 - UPPP_RALPJ

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, Rpic_0651
Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciRPIC402626:GH94-652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Rpic_0651
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000002566: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei203 – 22321Helical; Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Undecaprenyl-diphosphataseUniRule annotationPRO_1000197393Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402626.Rpic_0651.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2U7E0-1 [UniParc]FASTAAdd to Basket

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MDIALAIKAL ILGIVEGLTE FLPISSTGHL ILAGQLLDFN DEKGKIFEIV    50
IQFGAILAVC WEFRHKIIDV IKGLPNDPRQ QRFAINVIVA TIPAITLALI 100
FGKAIKAHLF NPIVVASAFI LGGFVILWAE WRERHRGETH DPRANALLEA 150
AKAGAPRIET LDDLRISDAI KVGFAQCFAL IPGTSRSGST IIGGLLFGLS 200
RKVATEFSFF LAIPVIFGAT VYELYKSRAL LSADDLSIFA VGFVAAFISA 250
FFCVRWLLKF IATHDFRGFA WYRIIFGIIV LATAYTHLIA WQA 293
Length:293
Mass (Da):32,233
Last modified:July 1, 2008 - v1
Checksum:iD335B2DEB105FF38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD25802.1.
RefSeqiYP_001898234.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD25802; ACD25802; Rpic_0651.
GeneIDi6288764.
KEGGirpi:Rpic_0651.
PATRICi20252170. VBIRalPic63053_1852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001068 Genomic DNA. Translation: ACD25802.1 .
RefSeqi YP_001898234.1. NC_010682.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402626.Rpic_0651.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD25802 ; ACD25802 ; Rpic_0651 .
GeneIDi 6288764.
KEGGi rpi:Rpic_0651.
PATRICi 20252170. VBIRalPic63053_1852.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci RPIC402626:GH94-652-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia pickettii 12J."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Marsh T., Richardson P.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12J.

Entry informationi

Entry nameiUPPP_RALPJ
AccessioniPrimary (citable) accession number: B2U7E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi