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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Ralstonia pickettii (strain 12J)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileUniRule annotation
Binding sitei110 – 1101SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciRPIC402626:GH94-2169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Rpic_2139
OrganismiRalstonia pickettii (strain 12J)
Taxonomic identifieri402626 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000002566 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274tRNA pseudouridine synthase APRO_1000097772Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi402626.Rpic_2139.

Structurei

3D structure databases

ProteinModelPortaliB2U6Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DI7. Bacteria.
COG0101. LUCA.
HOGENOMiHOG000248672.
KOiK06173.
OMAiYKLTIEY.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2U6Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRIALGIQY DGAAFSGWQS QPHGNTVQDA LESALRQFAG VALPTTVAGR
60 70 80 90 100
TDAGVHALGQ VVHLDTDLVR EPFSWVRGTN AFLPPTVAVR WAQEMPEDFH
110 120 130 140 150
ARFSAHRRTY YYALTFGPTR APLLEDKAGY VMLPPGQSLD VAAMNEAAQV
160 170 180 190 200
LVGEHDFSSF RAAECQAKSP VKTMYSIEVR GEGEWVFVRI RGSAFLHHMV
210 220 230 240 250
RNIMGCLVAI GRGRQPVSWM GDVLAARSRV AAAPTFMPDG LYLAEVGYPD
260 270
AFSLPASPAS SSLFRGVFDE HAGL
Length:274
Mass (Da):29,811
Last modified:July 1, 2008 - v1
Checksum:i3ACCE7C1ADCA0648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD27273.1.
RefSeqiWP_012436023.1. NC_010682.1.

Genome annotation databases

EnsemblBacteriaiACD27273; ACD27273; Rpic_2139.
GeneIDi6287815.
KEGGirpi:Rpic_2139.
PATRICi20255090. VBIRalPic63053_3287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001068 Genomic DNA. Translation: ACD27273.1.
RefSeqiWP_012436023.1. NC_010682.1.

3D structure databases

ProteinModelPortaliB2U6Z1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402626.Rpic_2139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD27273; ACD27273; Rpic_2139.
GeneIDi6287815.
KEGGirpi:Rpic_2139.
PATRICi20255090. VBIRalPic63053_3287.

Phylogenomic databases

eggNOGiENOG4105DI7. Bacteria.
COG0101. LUCA.
HOGENOMiHOG000248672.
KOiK06173.
OMAiYKLTIEY.

Enzyme and pathway databases

BioCyciRPIC402626:GH94-2169-MONOMER.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUA_RALPJ
AccessioniPrimary (citable) accession number: B2U6Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.