B2U3H4CYSG_SHIB3Siroheme synthaseUroporphyrinogen-III C-methyltransferaseUrogen III methylase2.1.1.107SUMTUroporphyrinogen III methylaseUROMPrecorrin-2 dehydrogenase1.3.1.76Sirohydrochlorin ferrochelatase4.99.1.4cysGSbBS512_E3744Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)BacteriaPseudomonadotaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigellaComplete sequence of Shigella boydii serotype 18 strain BS512.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteineNAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin2 H(+) + siroheme = Fe(2+) + sirohydrochlorinCofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.Cofactor biosynthesis; adenosylcobalamin biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.Porphyrin-containing compound metabolism; siroheme biosynthesis; siroheme from sirohydrochlorin: step 1/1.Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.In the C-terminal section; belongs to the precorrin methyltransferase family.Cobalamin biosynthesisLyaseMethyltransferaseMultifunctional enzymeNADOxidoreductasePhosphoproteinPorphyrin biosynthesisReference proteomeS-adenosyl-L-methionineTransferaseNAD(+)NAD(+)S-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionineMDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDTLNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFTTMSERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
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