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Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processDNA damage, DNA excision, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:SbBS512_E3504
OrganismiShigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Taxonomic identifieri344609 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001030 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001889711 – 168G/U mismatch-specific DNA glycosylaseAdd BLAST168

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2U1S3
SMRiB2U1S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000264684
KOiK03649
OMAiTGHHFAR

Family and domain databases

CDDicd10028 UDG_F2_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_01956 MUG, 1 hit
InterProiView protein in InterPro
IPR015637 MUG/TDG
IPR023502 MUG_bact
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159 PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit

Sequencei

Sequence statusi: Complete.

B2U1S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEDILAPGL RVVFCGINPG LSSAGTGFPF AHPANRFWKV IYQAGFTDRQ
60 70 80 90 100
LKPQEAQHLL DYRCGVTKLV DRPTVQANEV SKQELHAGGR KLIEKIEDYQ
110 120 130 140 150
PQALAILGKQ AYEQGFSQRG AQWGKQTLTI GSTQIWVLPN PSGLSRVSLE
160
KLVEAYRELD QALVVRGR
Length:168
Mass (Da):18,673
Last modified:July 1, 2008 - v1
Checksum:iF1CD9B2E2030D6A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA Translation: ACD06536.1

Genome annotation databases

EnsemblBacteriaiACD06536; ACD06536; SbBS512_E3504
KEGGisbc:SbBS512_E3504

Similar proteinsi

Entry informationi

Entry nameiMUG_SHIB3
AccessioniPrimary (citable) accession number: B2U1S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health