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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103Proton acceptorUniRule annotation1
Binding sitei121SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:SbBS512_E3334
OrganismiShigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Taxonomic identifieri344609 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001030 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000976941 – 219Ribose-5-phosphate isomerase AAdd BLAST219

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2U0T0
SMRiB2U0T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 31Substrate bindingUniRule annotation4
Regioni81 – 84Substrate bindingUniRule annotation4
Regioni94 – 97Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276368
KOiK01807
OMAiVAPMAYV

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

B2U0T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDELKKAV GWAALQYVQP GTIVGVGTGS TAAHFIDALG TMKGQIEGAV
60 70 80 90 100
SSSDASTEKL KSLGIHVFDL NEVDSLGIYV DGADEINGHM QMIKGGGAAL
110 120 130 140 150
TREKIIASVA EKFICIADAS KQVDILGKFP LPVEVIPMAR SAVARQLVKL
160 170 180 190 200
GGRPEYRQGV VTDNGNVILD VHGMEILDPI AMENAINAIP GVVTVGLFAN
210
RGADVALIGT PDGVKTIVK
Length:219
Mass (Da):22,860
Last modified:July 1, 2008 - v1
Checksum:iB53C49CC3DB188BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001063 Genomic DNA Translation: ACD07236.1

Genome annotation databases

EnsemblBacteriaiACD07236; ACD07236; SbBS512_E3334
KEGGisbc:SbBS512_E3334

Similar proteinsi

Entry informationi

Entry nameiRPIA_SHIB3
AccessioniPrimary (citable) accession number: B2U0T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health